{"id":"W4309014071","doi":"10.1093/neuonc/noac209.469","title":"EPCO-35. THE ZINC FINGER IN THE CEREBELLUM (ZIC1/4) LOCUS IS A CONTEXT DEPENDENT DRIVER GENE IN MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Epigenetics; Biology; Chromatin; Medulloblastoma; Genetics; Cancer research; Gene; Phenotype; High-mobility group; Context (archaeology); Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008037652,0.0001759813,0.0001542363,0.0003698325,0.0001340284,0.0001966359,0.0001749646,0.0001432044,0.001208568],"category_scores_gemma":[0.0001694849,0.0001309514,0.0001711936,0.0001979427,0.0001596025,0.00005998412,0.0001963337,0.0002153833,0.0002801015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625438,"about_ca_system_score_gemma":0.0002436146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00572595,"about_ca_topic_score_gemma":0.008477519,"domain_scores_codex":[0.999879,0.000007132103,0.000006814352,0.00004076915,0.0000436407,0.0000226674],"domain_scores_gemma":[0.9999409,0.000008169224,0.00002139679,0.000007913362,0.000005835626,0.00001586748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009791183,0.0000107163,0.006572418,0.0000233737,0.00001457853,0.0001999427,0.00001776208,0.0001358893,0.9907479,0.00007258925,0.00007294754,0.002034042],"study_design_scores_gemma":[0.00003839258,0.0002163602,0.4207035,0.00001372942,0.00008854991,0.0021513,0.00006637593,0.002758279,0.568036,0.0001632593,0.005752572,0.00001165971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99668,0.0003162739,0.001154679,0.00001640919,0.000005962556,0.0000218048,0.001070411,0.00007408391,0.0006603251],"genre_scores_gemma":[0.9968691,0.0001702803,0.000641622,0.00001250866,0.000001322756,0.00001423532,0.001220911,0.00001377227,0.00105624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00572595,"threshold_uncertainty_score":0.01138526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804259810641576,"score_gpt":0.2651107801450484,"score_spread":0.2470681820386326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}