{"id":"W4309016113","doi":"10.1093/neuonc/noac209.311","title":"CTNI-46. PIVOTAL STUDY TO EVALUATE SAFETY AND EFFICACY OF EXABLATE MODEL 4000 USING MICROBUBBLE RESONATORS TO TEMPORARILY MEDIATE BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Liquid biopsy; Oncology; Biomarker; Surrogate endpoint; Biopsy; Internal medicine; Cancer; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00288663,0.0009534167,0.001266649,0.0002043979,0.0003153425,0.0008162911,0.0006050054,0.0009713327,0.003018077],"category_scores_gemma":[0.001067331,0.0003697828,0.0008230841,0.0003405133,0.0006336026,0.0005169666,0.0002337105,0.001883824,0.0009322788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006010821,"about_ca_system_score_gemma":0.001376961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513362,"about_ca_topic_score_gemma":0.001225419,"domain_scores_codex":[0.9993093,0.0003504289,0.00003985316,0.0001116902,0.00008540112,0.0001031985],"domain_scores_gemma":[0.9989795,0.000125192,0.0002832098,0.000122971,0.0001358932,0.0003531763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7391612,0.02924651,0.008635984,0.0007634574,0.0007820267,0.0002546843,0.000130246,0.0009699466,0.1639804,0.0003069986,0.003728892,0.05203965],"study_design_scores_gemma":[0.1205264,0.8230385,0.0148148,0.00003739565,0.0006050145,0.0004129248,0.00004484343,0.0009132882,0.03527163,0.0001148581,0.004191043,0.00002927151],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873087,0.002744961,0.001806384,0.0004692648,0.0002140041,0.003026868,0.001813159,0.0001326972,0.00248402],"genre_scores_gemma":[0.9852237,0.001597095,0.00273769,0.0007515717,0.0002080019,0.00286505,0.003139626,0.00005119731,0.00342607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003018077,"threshold_uncertainty_score":0.01526612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692906695841938,"score_gpt":0.302412261277568,"score_spread":0.2854831943191486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}