{"id":"W4309016124","doi":"10.1093/neuonc/noac209.877","title":"EXTH-79. HIJACKING A NEURODEVELOPMENTAL EPIGENOMIC PROGRAM IN METASTATIC DISSEMINATION OF MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Cerebellum; Biology; Reelin; Epigenomics; Chromatin; Neuroscience; Transcription factor; DAB1; EZH2; Cancer research; Gene expression; Genetics; Gene; DNA methylation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001947025,0.0002703696,0.0003916221,0.0005210983,0.0002530869,0.0003504668,0.0002197201,0.0002011259,0.002870612],"category_scores_gemma":[0.0002049068,0.0001624319,0.0003226429,0.0005484941,0.000178848,0.0001864985,0.0004313621,0.0004177614,0.0009731863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003955345,"about_ca_system_score_gemma":0.0003270173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002419097,"about_ca_topic_score_gemma":0.00420844,"domain_scores_codex":[0.9997789,0.0000126969,0.00001328529,0.00008140804,0.00006989998,0.00004389423],"domain_scores_gemma":[0.9998367,0.00002425102,0.00006035305,0.00002299709,0.00001589875,0.00003985109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006427827,0.00005747567,0.04093258,0.0003289776,0.0001371799,0.0005839875,0.00007456441,0.001374451,0.9318732,0.0006900802,0.002793329,0.02051149],"study_design_scores_gemma":[0.0001193744,0.0003252901,0.5030691,0.00005479401,0.0002012061,0.001925513,0.0001455169,0.01486433,0.440908,0.001270304,0.03706344,0.00005311487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442735,0.001514187,0.006811462,0.0001295367,0.00004117097,0.00004290623,0.04302723,0.001234721,0.002925339],"genre_scores_gemma":[0.9418744,0.0006041684,0.004006456,0.0001879491,0.00001264387,0.00006637691,0.05045477,0.0001821646,0.002610989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002870612,"threshold_uncertainty_score":0.009603202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334317031301697,"score_gpt":0.3091570906527127,"score_spread":0.2958139203396958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}