{"id":"W4309016124","doi":"10.1093/neuonc/noac209.877","title":"EXTH-79. HIJACKING A NEURODEVELOPMENTAL EPIGENOMIC PROGRAM IN METASTATIC DISSEMINATION OF MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Cerebellum; Biology; Reelin; Epigenomics; Chromatin; Neuroscience; Transcription factor; DAB1; EZH2; Cancer research; Gene expression; Genetics; Gene; DNA methylation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602362,0.0001283435,0.0002168759,0.00009684672,0.00007593425,0.000006095845,0.0002058379,0.00005161402,0.00007860604],"category_scores_gemma":[0.0001154406,0.0001426182,0.00006902979,0.0001740968,0.00005889015,0.000003362773,0.0002362426,0.0001766934,0.000002160959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370529,"about_ca_system_score_gemma":0.0002723269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002007711,"about_ca_topic_score_gemma":0.00005665272,"domain_scores_codex":[0.9986593,0.0002418418,0.0003576081,0.0003476713,0.0001577543,0.0002357981],"domain_scores_gemma":[0.9994966,0.000064373,0.0001712065,0.0001895492,0.00003395255,0.00004430014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347264,0.0002983714,0.001078669,0.00002093774,0.00001596293,0.00002765634,0.0003386787,0.001291889,0.8974828,0.00001414191,0.0004599937,0.09883621],"study_design_scores_gemma":[0.003866429,0.008796784,0.01337446,0.00005275907,0.0001016876,0.0006893068,0.002750039,0.01298871,0.7376511,0.0002409967,0.2185855,0.0009022522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980484,0.0002808383,0.0001405744,0.0001836046,0.0003064229,0.0003611712,0.00001847978,0.00001859189,0.0006418801],"genre_scores_gemma":[0.9977393,0.00006390196,0.001516235,0.0002361783,0.00003799895,0.0002565902,0.00007985607,0.00002616443,0.00004375978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2181255,"threshold_uncertainty_score":0.58158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334317031301697,"score_gpt":0.3091570906527127,"score_spread":0.2958139203396958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}