{"id":"W4309016321","doi":"10.1093/neuonc/noac209.341","title":"DNAR-09. THE IMPACT OF MISMATCH REPAIR DEFICIENCY ON HIGH GRADE GLIOMAS IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS; A REPORT FROM THE IRRDC AND THE GLIOMA TASKFORCE","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Mount Sinai Hospital; Health Sciences Centre; University Health Network; University of Toronto; Sunnybrook Health Science Centre; Hospital for Sick Children","funders":"","keywords":"Microsatellite instability; DNA mismatch repair; Lynch syndrome; Medicine; Glioma; Germline mutation; Germline; Cancer; Internal medicine; Oncology; Cancer research; Mutation; Genetics; Biology; Gene; Allele; Microsatellite; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009162045,0.0002506131,0.0002173709,0.0007978821,0.0002112546,0.0003742122,0.0002365847,0.000300504,0.0011795],"category_scores_gemma":[0.001175587,0.000134937,0.0002454235,0.0009771163,0.0001051863,0.0001382953,0.0003243103,0.0003918344,0.0005761577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412479,"about_ca_system_score_gemma":0.0009728312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02244338,"about_ca_topic_score_gemma":0.02055339,"domain_scores_codex":[0.9995111,0.0001018263,0.00005224539,0.00007810322,0.0001873314,0.00006942452],"domain_scores_gemma":[0.9984307,0.0002125113,0.0005217376,0.00005206091,0.0004156724,0.0003672595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005022976,0.0001004738,0.9370322,0.0003832859,0.0001563415,0.0006882898,0.0001421343,0.0001209058,0.00136602,0.00007828613,0.01817834,0.04125157],"study_design_scores_gemma":[0.00004668903,0.0002603609,0.9776038,0.0001324858,0.0001136406,0.0008669595,0.0001725771,0.00006039705,0.0005998454,0.00001256702,0.02012268,0.000008007611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8075057,0.03873219,0.0006756842,0.003606106,0.000374941,0.0003732116,0.12859,0.000272725,0.01986935],"genre_scores_gemma":[0.9243965,0.01513356,0.001324651,0.001278288,0.0001889268,0.00027038,0.05350523,0.00006638617,0.003836113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02244338,"threshold_uncertainty_score":0.04462552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119122214105288,"score_gpt":0.2773429234042501,"score_spread":0.2661517012631972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}