{"id":"W4309016324","doi":"10.1093/neuonc/noac209.142","title":"STEM-25. IN VIVO FUNCTIONAL GENOMICS IDENTIFIES ESSENTIALITY OF POTASSIUM HOMEOSTASIS IN MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Biology; Functional genomics; Homeostasis; Transposable element; Cell biology; Gene; Cancer research; Genomics; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126463,0.0002128192,0.0001428874,0.0002862577,0.0001658916,0.0002431366,0.0002131831,0.0001934565,0.001854839],"category_scores_gemma":[0.00008090975,0.0001456258,0.0001775072,0.0001063399,0.0003082769,0.0001276865,0.0002031825,0.000341703,0.000309644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004715868,"about_ca_system_score_gemma":0.0002467113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179871,"about_ca_topic_score_gemma":0.002710824,"domain_scores_codex":[0.9999137,0.00001091813,0.000005951027,0.00002277397,0.00002857013,0.00001800944],"domain_scores_gemma":[0.9999053,0.00001608033,0.00003459976,0.000009271979,0.000006371098,0.00002845373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001733446,0.000004030708,0.0001084978,0.000006320546,9.191355e-7,0.00001416041,0.000004736421,0.00004358819,0.9992846,0.0001234639,0.00001172726,0.000380556],"study_design_scores_gemma":[0.000008830157,0.00009551962,0.006572087,0.000003326565,0.00001034263,0.0001917154,0.00001922512,0.001341254,0.988494,0.0001208858,0.003139401,0.000003426344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841139,0.0003777656,0.01175739,0.0001610866,0.00002394559,0.00003479023,0.001058337,0.0002770384,0.002195803],"genre_scores_gemma":[0.9916825,0.0002048937,0.003974706,0.00005501974,0.00000380545,0.00002083323,0.00091936,0.00006325708,0.003075504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001854839,"threshold_uncertainty_score":0.006205022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375607269982954,"score_gpt":0.2485940098425611,"score_spread":0.2348379371427316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}