{"id":"W4309016324","doi":"10.1093/neuonc/noac209.142","title":"STEM-25. IN VIVO FUNCTIONAL GENOMICS IDENTIFIES ESSENTIALITY OF POTASSIUM HOMEOSTASIS IN MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Biology; Functional genomics; Homeostasis; Transposable element; Cell biology; Gene; Cancer research; Genomics; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003874812,0.0001452704,0.0002848734,0.0001616178,0.00007223587,0.000009922946,0.0002419492,0.0001429131,0.0003110513],"category_scores_gemma":[0.00005229791,0.0001705244,0.00009820244,0.0002480097,0.0001242937,0.000006145836,0.0004211768,0.0002445936,0.000003723087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149041,"about_ca_system_score_gemma":0.0004408068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000980384,"about_ca_topic_score_gemma":0.0008639889,"domain_scores_codex":[0.9983946,0.0002775225,0.0004415172,0.0004294351,0.0001863136,0.0002706113],"domain_scores_gemma":[0.9993718,0.0000608243,0.0001847477,0.0002639363,0.00006726816,0.0000514647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004091009,0.0003590075,0.00459378,0.00004518546,0.00002133334,0.00006543359,0.0001389863,0.0008030414,0.9899037,0.00006645056,0.001699671,0.001894333],"study_design_scores_gemma":[0.001251859,0.0005727514,0.002494749,0.000002832514,0.00001849773,0.0001160528,0.0008887242,0.00005429456,0.8247043,0.0001558886,0.1695631,0.0001769432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966378,0.0008526083,0.0001081318,0.0003447721,0.0007862126,0.000179393,0.00009193293,0.000007902296,0.0009912794],"genre_scores_gemma":[0.9988492,0.0002399446,0.00002651308,0.0003859194,0.0001148076,0.00008181616,0.00007639197,0.0000211695,0.0002042952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1678634,"threshold_uncertainty_score":0.6953784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375607269982954,"score_gpt":0.2485940098425611,"score_spread":0.2348379371427316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}