{"id":"W4309016325","doi":"10.1093/neuonc/noac209.264","title":"CTIM-32. FIRST-IN-CHILDREN PHASE 1 TRIAL OF INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORS: ANALYSIS OF SAFETY, TOLERABILITY, AND 5-YEAR OUTCOME","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Temozolomide; Medulloblastoma; Regimen; Glioma; Ependymoma; Tolerability; Chemotherapy; Internal medicine; Radiation therapy; Surgery; Oncology; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001550947,0.001250148,0.001626154,0.0003220605,0.0003271895,0.0007603311,0.0006570231,0.0007019356,0.002254875],"category_scores_gemma":[0.0006335435,0.0004456415,0.001077758,0.0003512278,0.0009144629,0.0005070879,0.0002607037,0.00239638,0.000430901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001123341,"about_ca_system_score_gemma":0.002074786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009777644,"about_ca_topic_score_gemma":0.003695445,"domain_scores_codex":[0.9995634,0.0002366962,0.00001554135,0.0000677444,0.00003743796,0.00007924128],"domain_scores_gemma":[0.9994354,0.00007702837,0.0001734721,0.00005005267,0.00003630272,0.0002277625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8010769,0.04757,0.01553242,0.001205392,0.001868378,0.0002952148,0.0002568457,0.003369178,0.04591116,0.000446599,0.004549906,0.07791795],"study_design_scores_gemma":[0.4963242,0.4691855,0.02122307,0.00005822145,0.00102188,0.0003956907,0.00006154192,0.001391348,0.006339244,0.0002328418,0.003731671,0.00003460766],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923077,0.002556144,0.0003429217,0.0002462406,0.00007469115,0.002221515,0.001309429,0.000050886,0.0008905754],"genre_scores_gemma":[0.9885061,0.002177176,0.001700631,0.0004679502,0.0001373075,0.002848448,0.002222053,0.00002479279,0.001915603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002254875,"threshold_uncertainty_score":0.008202255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425346185207096,"score_gpt":0.3017858235590598,"score_spread":0.2875323617069889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}