{"id":"W4309016792","doi":"10.1093/neuonc/noac209.830","title":"EXTH-32. SEQUENTIAL SUNITINIB AND AURANOFIN TREATMENT INDUCEDCYTOTOXICITY THROUGH ROS-MEDIATED MECHANISM IN GLIOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Auranofin; Sunitinib; Cancer research; Temozolomide; Pharmacology; Reactive oxygen species; Angiogenesis; DNA damage; Cytotoxic T cell; Medicine; Chemistry; Cancer; Immunology; Glioma; Internal medicine; Biochemistry; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271493,0.0003809431,0.0005943859,0.0002998521,0.000196971,0.000172477,0.0002057246,0.0002630012,0.001786188],"category_scores_gemma":[0.00007336908,0.0001493127,0.0003520909,0.0002128967,0.0001347433,0.0001602752,0.0001784421,0.0003662732,0.0003530725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002840033,"about_ca_system_score_gemma":0.0003641319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001404,"about_ca_topic_score_gemma":0.001766596,"domain_scores_codex":[0.9998471,0.00002132092,0.00001641412,0.00002877286,0.00002912021,0.00005726228],"domain_scores_gemma":[0.9999598,0.000003203324,0.00000973154,0.000004850497,0.000006893394,0.00001538882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00239117,0.0003327528,0.000768813,0.0001700529,0.00003249958,0.0002003231,0.00003993942,0.0002017445,0.9862693,0.0000973092,0.0004041247,0.009091996],"study_design_scores_gemma":[0.0003136308,0.005785257,0.01730867,0.00001552473,0.00007307076,0.0006891549,0.00005155124,0.001928356,0.9698361,0.0001109022,0.003869314,0.00001847985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927827,0.003509376,0.0009779742,0.0001238035,0.0001109717,0.0001339826,0.0006790043,0.0001342167,0.001547867],"genre_scores_gemma":[0.9961184,0.0008281033,0.0006319894,0.00004629015,0.00001291425,0.0001006406,0.0008269443,0.000009021092,0.001425694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786188,"threshold_uncertainty_score":0.005975425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03953968774424947,"score_gpt":0.3114508108284254,"score_spread":0.2719111230841759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}