{"id":"W4309017257","doi":"10.1093/neuonc/noac209.059","title":"BIOM-49. A PILOT STUDY OF CEREBROSPINAL FLUID EXOSOMAL SMALL RNA-SEQUENCING IN PEDIATRIC MEDULLOBLASTOMA PATIENTS ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Cerebrospinal fluid; RNA; Biology; RNA extraction; Non-coding RNA; Oncology; Bioinformatics; Medicine; Internal medicine; Gene; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005082679,0.001094198,0.001271945,0.0003598229,0.001444813,0.001069694,0.001194811,0.001835684,0.0164996],"category_scores_gemma":[0.005402911,0.0005387571,0.001539297,0.0004517729,0.001099523,0.0007463871,0.001189867,0.001723472,0.004028391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001776858,"about_ca_system_score_gemma":0.007697486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002193065,"about_ca_topic_score_gemma":0.003132289,"domain_scores_codex":[0.9971486,0.001745598,0.0002054995,0.0004083803,0.0001767854,0.0003152136],"domain_scores_gemma":[0.9965474,0.0006099293,0.0004282241,0.00072463,0.0005294164,0.00116043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8190502,0.02819558,0.02258305,0.002380659,0.0009851962,0.0005745744,0.000518429,0.001791511,0.02441669,0.001509995,0.02649961,0.07149448],"study_design_scores_gemma":[0.4294279,0.4121301,0.08852895,0.0006772759,0.001415212,0.0004548347,0.0002916235,0.001464871,0.0125448,0.001910047,0.05103164,0.0001228054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6227946,0.001712314,0.008541488,0.002217992,0.00073893,0.3237312,0.02645488,0.0005195037,0.01328904],"genre_scores_gemma":[0.3679299,0.0006744026,0.01302533,0.003220692,0.0003727715,0.5891922,0.01939772,0.0001591219,0.006027825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0164996,"threshold_uncertainty_score":0.0551967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04850376539374591,"score_gpt":0.2943198196993315,"score_spread":0.2458160543055856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}