{"id":"W4309017270","doi":"10.1093/neuonc/noac209.295","title":"CTNI-30. LOGGIC/FIREFLY-2: A PHASE 3, RANDOMIZED TRIAL OF TOVORAFENIB VS. CHEMOTHERAPY IN PEDIATRIC PATIENTS WITH NEWLY DIAGNOSED LOW-GRADE GLIOMA HARBORING AN ACTIVATING RAF ALTERATION","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Regimen; Internal medicine; Chemotherapy regimen; Clinical endpoint; Oncology; Chemotherapy; Randomized controlled trial; Phases of clinical research; Glioma; Adverse effect; Cancer research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347114,0.002045889,0.002318023,0.0004569615,0.0004407716,0.001242342,0.001132434,0.001185849,0.006491811],"category_scores_gemma":[0.0009220167,0.0006733224,0.00161188,0.0004211365,0.001093818,0.001055312,0.0003623166,0.004202896,0.0009998669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001451722,"about_ca_system_score_gemma":0.002133517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002153029,"about_ca_topic_score_gemma":0.007080732,"domain_scores_codex":[0.9996381,0.0001649876,0.00001471352,0.00006467678,0.00003005966,0.00008754833],"domain_scores_gemma":[0.99932,0.0001029165,0.000131494,0.00004070732,0.00003512827,0.0003696664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.946192,0.01793168,0.0009101073,0.0006510726,0.0007617532,0.0001001329,0.00008237529,0.0008091768,0.006439116,0.0002420526,0.003423194,0.02245737],"study_design_scores_gemma":[0.8841859,0.111114,0.001617646,0.00003317977,0.0002747717,0.00008399996,0.0000319361,0.0007741259,0.0007058216,0.000168926,0.0009878146,0.00002189323],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831751,0.004590959,0.0005809881,0.001217084,0.0005768014,0.004655304,0.002089004,0.00029462,0.002820155],"genre_scores_gemma":[0.9789957,0.003304547,0.002109114,0.001548842,0.0003810775,0.006337968,0.002433798,0.00006047452,0.004828551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006491811,"threshold_uncertainty_score":0.02171725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657756764545945,"score_gpt":0.3039716173841623,"score_spread":0.2873940497387029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}