{"id":"W4309017638","doi":"10.1093/neuonc/noac209.879","title":"EXTH-81. ITGA5 IS A NOVEL IMMUNOTHERAPEUTIC TARGET AGAINST TREATMENT REFRACTORY MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"","keywords":"Medulloblastoma; Medicine; In vivo; Radiation therapy; Cytotoxic T cell; Oncology; Chemotherapy; Wnt signaling pathway; Primitive neuroectodermal tumor; Cancer research; Internal medicine; In vitro; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004892058,0.000197391,0.0002089383,0.0001587822,0.0001205987,0.0001892119,0.000163735,0.000185759,0.001440396],"category_scores_gemma":[0.00003821982,0.00006821426,0.0002096215,0.0001140356,0.00009235673,0.000101027,0.0001130342,0.0003725153,0.0003733149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003189064,"about_ca_system_score_gemma":0.0001711487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257792,"about_ca_topic_score_gemma":0.002306361,"domain_scores_codex":[0.9999597,0.000003321844,0.000001968878,0.000007275016,0.00001094448,0.00001674054],"domain_scores_gemma":[0.9999883,0.000001140508,0.00000247811,0.000001429435,0.000001786601,0.000004765629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004067602,0.0002974087,0.0006977726,0.0001446794,0.00002710134,0.0001538975,0.00003143304,0.001227243,0.9682484,0.0003579571,0.001150503,0.02725678],"study_design_scores_gemma":[0.0004596422,0.007054441,0.02593161,0.00005016046,0.0001983814,0.001776067,0.0001106001,0.01072047,0.9171401,0.0002579129,0.03627632,0.00002445388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905618,0.003012282,0.001574371,0.0001972732,0.0000735986,0.00008564572,0.0004111557,0.0001162478,0.00396766],"genre_scores_gemma":[0.9939179,0.001401293,0.0009717112,0.0001290823,0.00001165074,0.00004721093,0.0008746339,0.000009405051,0.002637074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440396,"threshold_uncertainty_score":0.004818618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02974117340433612,"score_gpt":0.302605193322135,"score_spread":0.2728640199177989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}