{"id":"W4309017983","doi":"10.1093/neuonc/noac209.169","title":"CSIG-20. PROTEOGENOMICS PROFILING REVEALS ENRICHED PROTEIN TRANSLATION REGULATORS AS NEW THERAPEUTIC TARGETS IN DIPG","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; Proteome; Histone; Epigenetics; Transcriptome; Histone H3; Proteomics; Gene knockdown; DNA methylation; Metabolome; Methylation; Translation (biology); Cell biology; Molecular biology; Cancer research; Genetics; Messenger RNA; Gene expression; Bioinformatics; Apoptosis; Metabolomics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295963,0.0003973907,0.0004985164,0.0004554772,0.0001902028,0.0003401301,0.0002030474,0.0002628749,0.0009886826],"category_scores_gemma":[0.0001318668,0.0001381754,0.0003496355,0.0006034623,0.000168923,0.0001295466,0.0001781179,0.0003751293,0.0004413144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718651,"about_ca_system_score_gemma":0.0002847931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114699,"about_ca_topic_score_gemma":0.001514713,"domain_scores_codex":[0.9999126,0.000007663068,0.000004698553,0.00002092258,0.0000312397,0.00002286709],"domain_scores_gemma":[0.9999509,0.000005280253,0.00001224261,0.000004699459,0.00001118241,0.00001559908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006652247,0.00003824898,0.002022354,0.000140448,0.00003092264,0.0001545663,0.00001351641,0.0001830369,0.990721,0.00004138948,0.0003566459,0.005632584],"study_design_scores_gemma":[0.00008595172,0.001033364,0.08081114,0.00002251355,0.0001732716,0.001576442,0.00006327453,0.00430744,0.9008335,0.0002050454,0.01086679,0.00002120935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818366,0.006559856,0.002607395,0.0002343263,0.00005446501,0.0001183265,0.006649925,0.0003407887,0.001598287],"genre_scores_gemma":[0.9784241,0.002805126,0.005319436,0.0002301239,0.00001710688,0.0001249054,0.01075387,0.00007140724,0.002253862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114699,"threshold_uncertainty_score":0.003307521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357431920842405,"score_gpt":0.285881132570665,"score_spread":0.2623068133622409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}