{"id":"W4309018553","doi":"10.1093/neuonc/noac209.1144","title":"MODL-16. SOMATICALLY ENGINEERED MOUSE MODELS RECAPITULATING CELLULAR AND MOLECULAR FEATURES OF HUMAN GBM","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"PTEN; Biology; CDKN2A; Cancer research; PDGFRA; Context (archaeology); Phenotype; Mesenchymal stem cell; Pathology; Stromal cell; PI3K/AKT/mTOR pathway; Gene; Genetics; Medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009192514,0.001342485,0.0005786485,0.001650518,0.0005099754,0.0007134465,0.001052102,0.001111259,0.007348577],"category_scores_gemma":[0.0001819494,0.00058679,0.0006195927,0.0007311173,0.0008884392,0.0006720168,0.000533817,0.001965129,0.003561604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006935424,"about_ca_system_score_gemma":0.0007183258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006006818,"about_ca_topic_score_gemma":0.001189806,"domain_scores_codex":[0.9993449,0.00007579129,0.0001233097,0.0001583145,0.0001597003,0.0001379374],"domain_scores_gemma":[0.999438,0.00004265264,0.0002764575,0.00007318447,0.00004128418,0.0001284514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004918756,0.0002625302,0.0005988183,0.0002120755,0.00002014484,0.0002187635,0.00008480824,0.0003306322,0.9923765,0.001537767,0.0007007779,0.003165409],"study_design_scores_gemma":[0.0002258956,0.001163594,0.00326236,0.00007482641,0.00006632642,0.001575164,0.00008023912,0.001839577,0.9625162,0.0005195166,0.02865424,0.00002195874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8943261,0.002752626,0.05237417,0.001235073,0.0005731019,0.001436467,0.03126858,0.003548961,0.01248494],"genre_scores_gemma":[0.8515196,0.003602,0.06320519,0.000611252,0.0001028138,0.003290256,0.01899095,0.001196153,0.05748181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007348577,"threshold_uncertainty_score":0.0245834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009580931457660003,"score_gpt":0.2737601221694131,"score_spread":0.2641791907117531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}