{"id":"W4309019023","doi":"10.1093/neuonc/noac209.1014","title":"TMET-09. LOSS OF MAT2A COMPROMISES METHIONINE METABOLISM AND REPRESENTS A VULNERABILITY IN H3K27M MUTANT GLIOMAS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hospital for Sick Children; McGill University","funders":"","keywords":"Epigenetics; Methionine Adenosyltransferase; Methionine; Methylation; Biology; Mutant; Methyltransferase; DNA methylation; Cancer research; Cell biology; Genetics; Chemistry; Gene; Gene expression; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383484,0.0003431812,0.0002844675,0.0003794045,0.0001984654,0.0003131345,0.0003287763,0.0004376153,0.003066564],"category_scores_gemma":[0.00008268508,0.0001605105,0.0003151285,0.0002761584,0.000322942,0.0002511054,0.0001708105,0.001196211,0.0006383294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781718,"about_ca_system_score_gemma":0.0003247986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008155372,"about_ca_topic_score_gemma":0.001106512,"domain_scores_codex":[0.9998354,0.00002054609,0.00001559675,0.00003794794,0.00004229408,0.00004818973],"domain_scores_gemma":[0.9999079,0.00001165291,0.00002315752,0.000009225325,0.000005336608,0.00004283285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006865169,0.000252913,0.0003821944,0.00003510246,0.00001363008,0.0001482003,0.00001361053,0.0001705004,0.9960027,0.0002776069,0.0001963258,0.001820679],"study_design_scores_gemma":[0.0001060926,0.002872199,0.004304488,0.000006034924,0.00002995188,0.001037504,0.00003394802,0.001427185,0.9856727,0.000116204,0.004386695,0.000006926238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927053,0.0005152918,0.001979887,0.0002446624,0.00009055153,0.0001087277,0.001976498,0.0001839209,0.002195222],"genre_scores_gemma":[0.9917613,0.0003842308,0.001474097,0.0001010428,0.00001017802,0.0001391381,0.001756568,0.0000418332,0.004331556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003066564,"threshold_uncertainty_score":0.01025867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042787843049634,"score_gpt":0.3095081475939314,"score_spread":0.2890802691634351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}