{"id":"W4309028333","doi":"10.1200/jco.22.01000","title":"Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric <i>BRAF</i> V600–Mutant Low-Grade Glioma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Brain Tumour Charity; Novartis Pharmaceuticals Corporation","keywords":"Trametinib; Dabrafenib; Medicine; Oncology; Dosing; Internal medicine; MEK inhibitor; Adverse effect; Pharmacology; Cancer; MAPK/ERK pathway; Kinase; Biology; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002325842,0.0001296882,0.001301619,0.0004390982,0.0000299939,0.000004290296,0.0001086495,0.0001443343,0.0001062196],"category_scores_gemma":[0.0007136009,0.00008264915,0.0001480078,0.0006285014,0.0001002441,0.00006147589,0.00003858493,0.0007195581,5.724038e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785436,"about_ca_system_score_gemma":0.0007653902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002725117,"about_ca_topic_score_gemma":0.00009352936,"domain_scores_codex":[0.9966198,0.0005557062,0.002061974,0.0001934782,0.0003854762,0.0001835377],"domain_scores_gemma":[0.9953365,0.002981619,0.001284886,0.000131753,0.00009644048,0.000168744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05555512,0.040741,0.7625342,0.00006868646,0.000256982,0.006089597,0.0005323439,0.0004707562,0.0006001269,0.0001988433,0.0001963927,0.132756],"study_design_scores_gemma":[0.1019804,0.04195095,0.8514901,0.00007560522,0.0002209208,0.0006559222,0.0001959635,0.0001128438,0.0002948834,0.0001382276,0.002795028,0.00008904489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916982,0.0006066791,0.000008365284,0.006898561,0.0002182954,0.0004561128,0.000004800878,0.000003881505,0.0001050784],"genre_scores_gemma":[0.9969712,0.001596272,0.0007579604,0.000507119,0.0001245687,0.0000171392,0.000002959267,0.0000158059,0.000006995309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326669,"threshold_uncertainty_score":0.3370335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05730024859899788,"score_gpt":0.4027940956124643,"score_spread":0.3454938470134664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}