{"id":"W4309035055","doi":"10.3390/cancers14225559","title":"Differences in Durability of PARP Inhibition by Clinically Approved PARP Inhibitors: Implications for Combinations and Scheduling","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Olaparib; PARP inhibitor; Cytotoxicity; Medicine; Poly ADP ribose polymerase; Cancer research; Pharmacology; Synthetic lethality; Drug; Oncology; Chemistry; In vitro; DNA repair; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001728108,0.0002643202,0.0004765463,0.0002049176,0.0001687861,0.0008251196,0.0005665735,0.00041732,0.001695355],"category_scores_gemma":[0.002508286,0.0002690786,0.0003057868,0.0003454537,0.0002409383,0.0008776631,0.0002204064,0.0009400079,0.0004444427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147367,"about_ca_system_score_gemma":0.0003309112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003255206,"about_ca_topic_score_gemma":0.0004110542,"domain_scores_codex":[0.9990329,0.0002822372,0.0001291324,0.0002170809,0.000232242,0.0001064949],"domain_scores_gemma":[0.9980944,0.0008972061,0.000406971,0.0003038387,0.0001644302,0.0001332305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004534104,0.0007044791,0.007175159,0.0001959023,0.00006545548,0.0001022753,0.0001473483,0.004110821,0.933684,0.0006506491,0.000372789,0.04825708],"study_design_scores_gemma":[0.000255548,0.009058206,0.03939007,0.00003269658,0.0001470185,0.0007667022,0.0002270255,0.008980166,0.9311299,0.0007884521,0.009180277,0.00004399906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685861,0.01204047,0.01372159,0.0003857307,0.0001822668,0.0001592197,0.0005813572,0.0001304427,0.00421269],"genre_scores_gemma":[0.9920975,0.001570514,0.004860839,0.0001233424,0.00004978902,0.00008707606,0.0002959032,0.00005236987,0.0008627304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728108,"threshold_uncertainty_score":0.00913918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04663301491096264,"score_gpt":0.3396292865219929,"score_spread":0.2929962716110303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}