{"id":"W4309046943","doi":"10.1038/s41467-022-34487-z","title":"Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Care Foundation","funders":"","keywords":"Vaccination; Influenza vaccine; Immunology; Immune system; Seroconversion; Multiplex; Vaccine efficacy; Medicine; Computational biology; Biology; Virology; Bioinformatics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002888721,0.0001660817,0.0004277521,0.0004366768,0.0001624992,0.0003971423,0.000129594,0.0002350432,0.0008446227],"category_scores_gemma":[0.000629194,0.0000936394,0.0003296608,0.0003828557,0.0001623571,0.000170535,0.0004082201,0.0002646165,0.0002876357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001074208,"about_ca_system_score_gemma":0.0001321485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008000672,"about_ca_topic_score_gemma":0.001011411,"domain_scores_codex":[0.9998672,0.00002941446,0.00001064797,0.0000438812,0.00001785189,0.00003103683],"domain_scores_gemma":[0.9998156,0.00005165629,0.00005476269,0.00003079567,0.00002401773,0.0000231114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001937415,0.0001739719,0.7822259,0.0003331154,0.000356264,0.0003288128,0.0007418501,0.004052599,0.1731542,0.0004281797,0.00228758,0.03398006],"study_design_scores_gemma":[0.00001405869,0.0002744203,0.9843301,0.00002483171,0.000114662,0.0003891712,0.0004592457,0.005582915,0.005260515,0.001042409,0.002488861,0.00001883847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949991,0.0003459859,0.001154943,0.00003567755,0.000004804821,0.000009890278,0.003120116,0.00001828105,0.0003112868],"genre_scores_gemma":[0.9923162,0.0002694371,0.001293601,0.00006026018,0.00001454285,0.00004355164,0.005699745,0.000007713523,0.0002949355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008446227,"threshold_uncertainty_score":0.002825558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06824010337183387,"score_gpt":0.4057333977314838,"score_spread":0.3374932943596499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}