{"id":"W4309047234","doi":"10.1016/j.ejca.2022.11.007","title":"Association and performance of polygenic risk scores for breast cancer among French women presenting or not a familial predisposition to the disease","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancéropôle Ile de France; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer; Association for International Cancer Research; National Cancer Institute; Institut National Du Cancer; Cancer Research UK; European Commission; Fondation du cancer du sein du Québec; Génome Québec","keywords":"Breast cancer; Medicine; Oncology; Odds ratio; Family history; Hazard ratio; Internal medicine; Population; Single-nucleotide polymorphism; Cancer; Receiver operating characteristic; Demography; Confidence interval; Genetics; Environmental health; Biology; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002727912,0.0005065852,0.0002576736,0.002030851,0.0003193835,0.0006512735,0.0002613475,0.0005468795,0.001228347],"category_scores_gemma":[0.006406203,0.000108883,0.0007058313,0.0007453635,0.0003376849,0.0002007445,0.0003910793,0.0002261411,0.0001594095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006838236,"about_ca_system_score_gemma":0.0003450961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02573561,"about_ca_topic_score_gemma":0.01671295,"domain_scores_codex":[0.998978,0.0005099315,0.00006760607,0.0001894395,0.000139522,0.0001153739],"domain_scores_gemma":[0.9965526,0.001512708,0.0009969332,0.0002798103,0.0004348335,0.0002230979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001184726,0.000007520915,0.9966832,0.00000536324,0.0001050555,0.00005281806,0.00005490837,0.0001665965,0.0001916997,0.0000320853,0.00009227749,0.002489921],"study_design_scores_gemma":[0.000005984358,0.00006996387,0.9984906,0.000004255647,0.00004820475,0.0002524451,0.0000475456,0.0008079331,0.00005907003,0.00003475606,0.0001749346,0.0000042926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985374,0.0003435565,0.0002594055,0.00006968946,0.000004582062,0.000004770597,0.0002210333,0.00001210364,0.000547533],"genre_scores_gemma":[0.9994276,0.00006743884,0.0001371865,0.00001341474,0.000006365795,0.000003762835,0.0002683554,0.000001545703,0.00007433193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02573561,"threshold_uncertainty_score":0.05117166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007315677548566145,"score_gpt":0.2478647363540857,"score_spread":0.2405490588055195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}