{"id":"W4309097338","doi":"10.1128/jvi.01476-22","title":"The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"IRF3; Sting; Autophagy; Stimulator of interferon genes; Biology; Interferon; TANK-binding kinase 1; Vesicular stomatitis virus; ULK1; Innate immune system; Virus; RIG-I; DNA virus; Mutant; Interferon regulatory factors; Virology; Cell biology; Apoptosis; Kinase; Immune system; Immunology; Biochemistry; Gene; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00122886,0.0001474877,0.0003863319,0.0002280025,0.0003690833,0.00001229719,0.0002753681,0.0001348776,0.0002872928],"category_scores_gemma":[0.000156911,0.0001045562,0.0001103892,0.00008149494,0.0002743912,0.000127634,0.0002272883,0.0007535581,0.000008574282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005004432,"about_ca_system_score_gemma":0.00008846281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002964271,"about_ca_topic_score_gemma":0.00003328374,"domain_scores_codex":[0.9976988,0.001133071,0.0006571789,0.0001572385,0.00007266887,0.0002809704],"domain_scores_gemma":[0.9986859,0.0003618647,0.0006572276,0.0001885974,0.00008364235,0.00002278804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009459794,0.0002204603,0.001196933,0.000006823451,0.0002082738,0.00002876411,0.0005524852,0.00001945914,0.9713173,0.0003923798,0.0003983535,0.01619899],"study_design_scores_gemma":[0.008103339,0.05115321,0.09213839,0.00008033244,0.0003230747,0.01138751,0.006027241,0.00008811379,0.7317998,0.000789216,0.0975993,0.0005104136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992718,0.004679015,0.000165083,0.0003340306,0.001844984,0.00008446299,0.00001235108,0.0000106653,0.0001513834],"genre_scores_gemma":[0.9988903,0.0001244852,0.000009599167,0.0001759594,0.0000546557,0.000004547982,0.000009929959,0.00001448797,0.0007160148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2395174,"threshold_uncertainty_score":0.4263677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354713999350764,"score_gpt":0.2476799397505884,"score_spread":0.2341327997570807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}