{"id":"W4309097338","doi":"10.1128/jvi.01476-22","title":"The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"IRF3; Sting; Autophagy; Stimulator of interferon genes; Biology; Interferon; TANK-binding kinase 1; Vesicular stomatitis virus; ULK1; Innate immune system; Virus; RIG-I; DNA virus; Mutant; Interferon regulatory factors; Virology; Cell biology; Apoptosis; Kinase; Immune system; Immunology; Biochemistry; Gene; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009131549,0.0001990941,0.0001498733,0.0002214996,0.0001124998,0.0002504077,0.00008094,0.000196364,0.0004323192],"category_scores_gemma":[0.00005999545,0.00006307135,0.0002397481,0.00009737672,0.0002392125,0.0002760526,0.0001430743,0.0002717341,0.0001527902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001812129,"about_ca_system_score_gemma":0.0001627766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001362815,"about_ca_topic_score_gemma":0.0003136485,"domain_scores_codex":[0.9999388,0.00001387808,0.000004441229,0.00001201903,0.00001070831,0.00002014308],"domain_scores_gemma":[0.9999535,0.000008320172,0.00001423033,0.000007701949,0.00000362759,0.00001270324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006403014,0.000005102823,0.0003747719,0.00002021692,0.000002107974,0.00007368707,0.000007011519,0.00004115294,0.9978928,0.0001639255,0.00001370126,0.001341428],"study_design_scores_gemma":[0.00001284038,0.000490138,0.01898405,0.00001494407,0.00002008381,0.001724552,0.00005794238,0.00176428,0.9717,0.0004403067,0.004782269,0.000008704294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906557,0.002778976,0.003400367,0.00007976677,0.00002259222,0.00001190202,0.0001495467,0.00004019146,0.002860948],"genre_scores_gemma":[0.9968717,0.0005919415,0.001627828,0.00002909853,0.000009142683,0.000006810262,0.000192569,0.000004926339,0.0006659086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004323192,"threshold_uncertainty_score":0.001446247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354713999350764,"score_gpt":0.2476799397505884,"score_spread":0.2341327997570807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}