{"id":"W4309098868","doi":"10.1016/j.vaccine.2022.11.002","title":"Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum","year":2022,"lang":"en","type":"article","venue":"Vaccine","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; University of Victoria","keywords":"Chancre; Syphilis; Treponema; Immunology; Medicine; Virology; Immunization; Transmission (telecommunications); Public health; Sexually transmitted disease; Antigen; Human immunodeficiency virus (HIV); Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878236,0.0003517813,0.000321596,0.0003402071,0.000095484,0.0002112352,0.0002066428,0.0003840002,0.001265018],"category_scores_gemma":[0.0001751864,0.0001028003,0.0002192835,0.00008411186,0.0002061208,0.0002222618,0.0001531779,0.0009548345,0.0002129495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479473,"about_ca_system_score_gemma":0.0002839237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003488243,"about_ca_topic_score_gemma":0.0005017117,"domain_scores_codex":[0.9998511,0.00002516039,0.00001204742,0.00002196917,0.00004203309,0.00004757381],"domain_scores_gemma":[0.9998982,0.0000163095,0.00002723135,0.00001086763,0.0000123873,0.00003509999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005095254,0.0008928134,0.0003222049,0.00007647515,0.00001744169,0.00004956936,0.00002242485,0.0001657031,0.9898368,0.000123097,0.0001592528,0.007824743],"study_design_scores_gemma":[0.0002267446,0.0199544,0.01058021,0.0000347453,0.00009229475,0.0007622142,0.00005028168,0.002505975,0.9624625,0.00009310694,0.003228128,0.000009418877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948798,0.0009340318,0.002206363,0.0001767328,0.00006832577,0.00006750194,0.00008317415,0.0001002525,0.001483767],"genre_scores_gemma":[0.9956,0.0008066004,0.001753122,0.0001015793,0.000030942,0.00003610552,0.0002029823,0.00001072787,0.001457754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265018,"threshold_uncertainty_score":0.00423193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222108136514714,"score_gpt":0.2485705313509302,"score_spread":0.2363494499857831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}