{"id":"W4309108398","doi":"10.1158/1538-7445.panca22-b024","title":"Abstract B024: Phosphoinositide focused CRISPR screen reveals ITGAV as a critical gene in pancreatic cancer growth and invasion","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Biology; KRAS; Cancer; Pancreatic cancer; Signal transduction; Gene; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163037,0.0006394918,0.0003622561,0.000418222,0.0002347422,0.0003946256,0.000312276,0.0005138674,0.002543981],"category_scores_gemma":[0.0001432817,0.0001595998,0.0004482011,0.0002815489,0.0002442724,0.0001151565,0.0002732802,0.0006278819,0.0008718682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003869335,"about_ca_system_score_gemma":0.0003307895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105015,"about_ca_topic_score_gemma":0.001517269,"domain_scores_codex":[0.9998106,0.00001574176,0.00001929052,0.00004983057,0.00007057015,0.00003396247],"domain_scores_gemma":[0.9998155,0.00004424113,0.00005489001,0.0000194852,0.0000173207,0.00004849772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007596933,0.00001750323,0.0002652336,0.00002926687,0.000006319126,0.000129966,0.000005997556,0.0001678272,0.9980793,0.00007059206,0.0001098016,0.001042229],"study_design_scores_gemma":[0.00002164125,0.0001806004,0.008049661,0.00001489303,0.00004993507,0.0006750808,0.00003480595,0.002928154,0.9833819,0.00009299741,0.004558245,0.00001213969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646906,0.0008963859,0.0199209,0.0003559825,0.0001195971,0.0001322207,0.007966157,0.001466517,0.004451663],"genre_scores_gemma":[0.9766911,0.0005229657,0.01128963,0.000188305,0.00001042429,0.00008784775,0.005064016,0.0002703265,0.005875428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543981,"threshold_uncertainty_score":0.00851047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05291283046190505,"score_gpt":0.4047778135306629,"score_spread":0.3518649830687579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}