{"id":"W4309108403","doi":"10.1158/1538-7445.panca22-b075","title":"Abstract B075: Sirtuin 6 histone deacetylase is required for the integrated stress response and resistance to inhibition of transcriptional cyclin dependent kinases in Pancreatic Ductal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cancer research; Histone deacetylase; Sirtuin; Biology; Cyclin-dependent kinase; Kinase; SIRT6; Histone; HDAC6; Histone deacetylase inhibitor; Cell biology; Acetylation; Cancer; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208227,0.0001994068,0.0002729459,0.0002287539,0.0001716396,0.0003340097,0.0002035937,0.0002315031,0.002392128],"category_scores_gemma":[0.0001348532,0.0001163505,0.0003295257,0.0002387201,0.00019687,0.0001297027,0.0001613129,0.0004295799,0.0009200059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273376,"about_ca_system_score_gemma":0.0001781427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364696,"about_ca_topic_score_gemma":0.0007762504,"domain_scores_codex":[0.9998713,0.00001498932,0.00001686941,0.0000317019,0.00004246462,0.00002267077],"domain_scores_gemma":[0.9998524,0.00001393514,0.00004342106,0.00002176778,0.00001751317,0.00005094589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001555293,0.00001709427,0.0008967817,0.00002229628,0.000006460265,0.00004023935,0.000006044355,0.00003319093,0.9976895,0.00006003639,0.00007016515,0.001002664],"study_design_scores_gemma":[0.00002536477,0.0002482278,0.04151559,0.000006249242,0.00002455682,0.0005272965,0.00004525343,0.001011454,0.9521732,0.00006613952,0.004350383,0.000006388946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911739,0.001532157,0.002911733,0.0001730548,0.0000625358,0.00002091894,0.002591037,0.0001560208,0.001378631],"genre_scores_gemma":[0.9938372,0.0003477603,0.001213545,0.00006850484,0.000008843176,0.00001172435,0.002558044,0.00002687241,0.001927422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002392128,"threshold_uncertainty_score":0.00800252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04475399065094296,"score_gpt":0.3519784245884361,"score_spread":0.3072244339374932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}