{"id":"W4309138955","doi":"10.1371/journal.pone.0277097","title":"Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; University of Regina","funders":"Natural Sciences and Engineering Research Council of Canada; University of Illinois at Urbana-Champaign; Canada Foundation for Innovation; Canada Research Chairs; Saskatchewan Health Research Foundation; University of Regina; Brown University","keywords":"Essential oil; Rosmarinus; Reactive oxygen species; Candida albicans; Microbiology; Biology; Corpus albicans; Biofilm; Virulence; Chemistry; Botany; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009497302,0.0004403846,0.0002786004,0.0002558873,0.00008625953,0.0002245476,0.0001590891,0.0002140487,0.0006136236],"category_scores_gemma":[0.0001035371,0.0001207233,0.0003332965,0.0001015203,0.0001065588,0.0001439364,0.0001836572,0.0004129961,0.000166839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000910068,"about_ca_system_score_gemma":0.0001594618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007114707,"about_ca_topic_score_gemma":0.0009665038,"domain_scores_codex":[0.9998792,0.00002142211,0.0000151812,0.00001936872,0.00003474662,0.00002998187],"domain_scores_gemma":[0.9999168,0.00001369698,0.00002417748,0.000009718507,0.00001582576,0.00001977002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096665,0.00003009415,0.00007584113,0.00002249786,0.000003853293,0.00003100562,0.000006198877,0.00002739879,0.9991497,0.000007609277,0.00000661528,0.0005295925],"study_design_scores_gemma":[0.000009188846,0.0004137207,0.002696771,0.000005111593,0.00001449723,0.0000994146,0.00001597688,0.0002503746,0.9960755,0.00001224828,0.0004045584,0.000002709721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966723,0.00165758,0.0007017204,0.00004067124,0.00001216501,0.0000165351,0.0001962548,0.00003540031,0.0006673855],"genre_scores_gemma":[0.9968227,0.0007556278,0.0009608961,0.00002919269,0.000005877812,0.00001270377,0.0002930836,0.000008226124,0.001111652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007114707,"threshold_uncertainty_score":0.002052784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.036701131504898,"score_gpt":0.2491490218462883,"score_spread":0.2124478903413903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}