{"id":"W4309146118","doi":"10.1101/2022.11.15.516351","title":"Inflammation durably imprints memory CD4+ T cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; National Center for Advancing Translational Sciences; LEO Fondet; York University; Georgia Clinical and Translational Science Alliance","keywords":"Biology; Priming (agriculture); Epigenetics; Immunology; Immune system; Vaccination; T cell; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173743,0.0002530637,0.000352796,0.0002739556,0.0002049274,0.0006536022,0.0001628187,0.0003197491,0.001767825],"category_scores_gemma":[0.000370241,0.0002487245,0.000241549,0.0001926019,0.0002697218,0.0003175006,0.000453022,0.0004770901,0.000455723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719821,"about_ca_system_score_gemma":0.0002562592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287414,"about_ca_topic_score_gemma":0.0008614673,"domain_scores_codex":[0.9996901,0.0000456672,0.00001399802,0.0001078597,0.00005791801,0.00008453921],"domain_scores_gemma":[0.9998179,0.000036909,0.00005883766,0.0000274527,0.00002440932,0.00003440576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006619158,0.00004673651,0.03902464,0.0001072645,0.00005451694,0.0001534502,0.0002291686,0.0003639647,0.9407305,0.0003041294,0.0001606608,0.01816306],"study_design_scores_gemma":[0.00003286315,0.001503789,0.6909826,0.00006502146,0.0002070737,0.0006279763,0.0007223063,0.001999016,0.2947469,0.001519189,0.007556855,0.00003645565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947436,0.001303031,0.001783299,0.0000687542,0.00002866867,0.00001520672,0.0002998642,0.00005404196,0.001703579],"genre_scores_gemma":[0.9975726,0.0003347904,0.0007331161,0.00008915256,0.00002872504,0.00002417913,0.0002550577,0.00001313312,0.0009491445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001767825,"threshold_uncertainty_score":0.005913913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009938900790696722,"score_gpt":0.2016210918894855,"score_spread":0.1916821910987888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}