{"id":"W4309150259","doi":"10.21203/rs.3.rs-2255626/v1","title":"Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Hepatitis C virus research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers","keywords":"Germline; Epitope; Virology; Glycoprotein; Antibody; Hepatitis C virus; Biology; Virus; Computational biology; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009299249,0.0001676663,0.00008213741,0.0001986178,0.0001077949,0.0002355327,0.00009472376,0.0002250191,0.00200247],"category_scores_gemma":[0.0001496093,0.00007982214,0.0000982239,0.00007670099,0.00009926058,0.00008083341,0.0001319029,0.0002824593,0.0004377033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065822,"about_ca_system_score_gemma":0.00008026225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006353789,"about_ca_topic_score_gemma":0.0004763644,"domain_scores_codex":[0.9999331,0.00001022425,0.000002726134,0.00001187608,0.00001420514,0.00002790044],"domain_scores_gemma":[0.9999347,0.00001418904,0.00001310175,0.00000513746,0.00001399251,0.00001888187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008399801,0.000009785225,0.000528448,0.000008535712,0.000001811789,0.00003535522,0.00001443049,0.0000531966,0.9983093,0.0001231351,0.00003909382,0.0007929356],"study_design_scores_gemma":[0.00002014272,0.0002491474,0.02432055,0.000007071401,0.000009304245,0.0006802644,0.00008678496,0.004426546,0.9671708,0.0002207437,0.002802645,0.000005883249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963529,0.0001714903,0.001268165,0.00002427009,0.000007186728,0.00001084562,0.000115713,0.00003210708,0.002017215],"genre_scores_gemma":[0.9970543,0.00007413053,0.001069856,0.00004013653,0.000004181724,0.000008306055,0.000288208,0.00001429955,0.001446477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200247,"threshold_uncertainty_score":0.006698966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06932868358177449,"score_gpt":0.426624178876587,"score_spread":0.3572954952948125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}