{"id":"W4309153013","doi":"10.3390/ijms232214122","title":"Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Faculty of Medicine and Health, University of Sydney; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Priming (agriculture); Antigen; Biology; Cytokine; Cytotoxic T cell; Chromatin; Cell biology; CD8; Immunology; Antigen-presenting cell; Immune system; T cell; Molecular biology; Gene; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122928,0.0001855659,0.0001541283,0.0001609532,0.00009232151,0.0002919356,0.00007983995,0.0001595942,0.00183026],"category_scores_gemma":[0.0001491948,0.00008622903,0.0001025471,0.0001057415,0.0001706523,0.0001725906,0.0001528214,0.0002792077,0.0002812135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007792377,"about_ca_system_score_gemma":0.00007896052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006508363,"about_ca_topic_score_gemma":0.0001625099,"domain_scores_codex":[0.9998764,0.0000258539,0.000008817327,0.00002919362,0.00002359099,0.00003611255],"domain_scores_gemma":[0.9998993,0.00002437637,0.00002727426,0.000008687171,0.00001365141,0.00002664388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008835647,0.000008432436,0.000420619,0.00001687836,0.000001076283,0.00002020815,0.00001451762,0.00001639812,0.9987907,0.00001944285,0.000007527709,0.0005958971],"study_design_scores_gemma":[0.00002531758,0.0005147156,0.0414802,0.00001351825,0.0000166936,0.0002700344,0.0001287981,0.0005912774,0.9555158,0.0001194586,0.001319199,0.000004965181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974082,0.0008397007,0.0008506837,0.00002648927,0.00001223204,0.00001270626,0.000100375,0.00002100261,0.0007285403],"genre_scores_gemma":[0.9980971,0.0003439029,0.0007110108,0.0000291781,0.000009949867,0.00001794984,0.0001304388,0.000005810264,0.0006546913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183026,"threshold_uncertainty_score":0.006122768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542706613395629,"score_gpt":0.3587984025869215,"score_spread":0.3333713364529652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}