{"id":"W4309191159","doi":"10.1158/1538-7445.panca22-c075","title":"Abstract C075: The loss of ATRX induces a sex-specific progression of pancreatic ductal adenocarcinoma in the presence of oncogenic KRASG12D","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"ATRX; Cancer research; Pancreatic cancer; Biology; Cancer; Synthetic lethality; Pancreas; Pathology; Medicine; DNA repair; Internal medicine; Endocrinology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001420449,0.00008649586,0.0001631959,0.00006106532,0.0001182331,0.000008440597,0.0007175817,0.00005439795,0.00009817832],"category_scores_gemma":[0.0000580738,0.00005466528,0.00008074316,0.000380847,0.0003844735,0.000003723297,0.0002885126,0.0003418807,4.152292e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004212846,"about_ca_system_score_gemma":0.0004082004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006602664,"about_ca_topic_score_gemma":0.00005958843,"domain_scores_codex":[0.9981399,0.0003439485,0.0003061576,0.0002505418,0.0007149676,0.0002444565],"domain_scores_gemma":[0.9990728,0.0001105691,0.0001385046,0.0005221181,0.0001304794,0.00002546671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003109358,0.00014288,0.01494775,0.0001746395,0.00004734773,0.000006807523,0.001853852,0.0006604093,0.9764422,0.00006770872,0.0007037168,0.004641779],"study_design_scores_gemma":[0.0008459403,0.0008434574,0.05695926,0.0002008576,0.00001986685,0.0000318167,0.006302648,0.0001232494,0.9312162,0.0003599508,0.00294127,0.0001554277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744281,0.02458662,0.000002987055,0.0002535894,0.00005148777,0.0003888021,0.00006057134,0.000001682158,0.0002261168],"genre_scores_gemma":[0.9980265,0.00149089,0.00002129309,0.00001149768,0.00009876014,0.0002335706,0.00001613151,0.00001257842,0.00008871071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04522591,"threshold_uncertainty_score":0.2229186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06153521463569821,"score_gpt":0.3809156703948701,"score_spread":0.3193804557591718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}