{"id":"W4309202711","doi":"10.1172/jci159344","title":"Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université de Montréal; Montreal Neurological Institute and Hospital; Canadian Sleep & Circadian Network; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Parvalbumin; Interneuron; Neuroscience; Hippocampus; Memory consolidation; Excitatory postsynaptic potential; Inhibitory postsynaptic potential; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002723163,0.0007478957,0.0004420861,0.0007983598,0.0002641673,0.0004047313,0.0006480937,0.0007763496,0.001407755],"category_scores_gemma":[0.0002095608,0.0003866011,0.000407928,0.0002223617,0.0006270374,0.0005433526,0.0003800419,0.001723558,0.0004370129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044934,"about_ca_system_score_gemma":0.0003585423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000891529,"about_ca_topic_score_gemma":0.00189453,"domain_scores_codex":[0.9996821,0.00002945089,0.00003664391,0.00009784194,0.00005760268,0.00009652366],"domain_scores_gemma":[0.9996033,0.00002562908,0.0002030696,0.00003430327,0.00002506584,0.0001087059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003726308,0.0002106436,0.0007329731,0.00004384982,0.00001715998,0.0002051828,0.0000543727,0.00008889403,0.9954618,0.000132079,0.00007445346,0.002606011],"study_design_scores_gemma":[0.0001421644,0.002477279,0.02138759,0.00004833699,0.00009598264,0.001315835,0.0001262367,0.001733012,0.9703928,0.0002389896,0.002023129,0.00001869831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949903,0.001005143,0.002479607,0.0001489907,0.00003313271,0.0000542807,0.0004285728,0.0002022776,0.0006577898],"genre_scores_gemma":[0.9922694,0.001112661,0.002349973,0.0001472774,0.00002227288,0.0001840812,0.000572118,0.00007132271,0.003270854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407755,"threshold_uncertainty_score":0.004709363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1612508370848418,"score_gpt":0.3902950435024435,"score_spread":0.2290442064176017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}