{"id":"W4309222061","doi":"10.20944/preprints202210.0023.v2","title":"Synergistic Cooperation Involving TGFβ1-mediated Crosstalk Enhances the Invasiveness of Genetically Distant Cancer Clones<strong></strong>","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Mathematical Biology Tumor Growth","field":"Mathematics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"China Scholarship Council; New Brunswick Innovation Foundation","keywords":"Cancer research; Phenotype; Biology; Metastasis; Cell culture; Breast cancer; Epigenetics; Phenotypic plasticity; Transforming growth factor; Transforming growth factor beta; Cancer; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720952,0.000323921,0.0003215546,0.000210463,0.0001479413,0.0003899576,0.000165189,0.0002207774,0.001318165],"category_scores_gemma":[0.0001041137,0.0001600393,0.0003202476,0.0001310668,0.0001496836,0.0001752884,0.0003981089,0.000617929,0.0003972873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971102,"about_ca_system_score_gemma":0.000240818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004190475,"about_ca_topic_score_gemma":0.001208966,"domain_scores_codex":[0.9997414,0.00004750766,0.00001682831,0.00004455306,0.00008223741,0.00006756566],"domain_scores_gemma":[0.9998435,0.00002923578,0.00003090766,0.00002711387,0.00001857613,0.00005069666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004397206,0.00002176441,0.0003128218,0.00001930643,0.000004673168,0.0000408971,0.0000153982,0.00002576759,0.9984627,0.00005336903,0.00002771739,0.0009718392],"study_design_scores_gemma":[0.00001752491,0.0004793392,0.01557784,0.000006478251,0.00004400155,0.0004055883,0.000105623,0.001535291,0.9786624,0.00008080353,0.003076744,0.000008351457],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951456,0.0009397704,0.001885914,0.00008489547,0.00002484414,0.00002161516,0.0001067067,0.00004999174,0.001740661],"genre_scores_gemma":[0.995566,0.0003790924,0.001635779,0.00006833639,0.00001297615,0.00003209816,0.0001426773,0.000009416227,0.002153679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318165,"threshold_uncertainty_score":0.004409671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176753070576478,"score_gpt":0.3638651246738512,"score_spread":0.2461898176162034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}