{"id":"W4309244247","doi":"10.1097/txd.0000000000001406","title":"Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Kidney Transplant Rejection: Effect on Donor-derived Cell-free DNA and C-X-C Motif Chemokine Ligand 10","year":2022,"lang":"en","type":"article","venue":"Transplantation Direct","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Medicine; Interquartile range; Creatinine; Internal medicine; Antibody; Immunology; Chemokine; Placebo; Gastroenterology; Endocrinology; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003876041,0.0005362912,0.0008857027,0.0006082942,0.0003069681,0.000052405,0.0001938574,0.0001451204,0.0005563576],"category_scores_gemma":[0.00003052225,0.0004776704,0.0002270514,0.0006639451,0.00008597995,0.00018202,0.00001752371,0.0004946132,0.0000429764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889146,"about_ca_system_score_gemma":0.0001178234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002392935,"about_ca_topic_score_gemma":0.00004365563,"domain_scores_codex":[0.9970182,0.0003061818,0.0006845588,0.0008058654,0.000676233,0.0005089677],"domain_scores_gemma":[0.9985675,0.000447599,0.0001769684,0.0004312556,0.00005068858,0.000326009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01663878,0.001725635,0.2576549,0.003656516,0.0006395641,0.005046819,0.004538334,0.0003982102,0.7082832,0.00004842252,0.0002715302,0.001098049],"study_design_scores_gemma":[0.04415906,0.004754907,0.4844832,0.001553348,0.00113143,0.001479615,0.0001346647,0.0005767136,0.4597772,0.00002089544,0.001069711,0.0008592805],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890224,0.0002468148,0.0001110037,0.0006209821,0.000418327,0.001213697,0.001106373,0.0002282842,0.007032163],"genre_scores_gemma":[0.9901037,0.002268043,0.00008722232,0.0005535288,0.00007132954,0.0001284632,0.006010229,0.00007791688,0.0006995806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.248506,"threshold_uncertainty_score":0.9997675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009883517151941742,"score_gpt":0.2704516861973411,"score_spread":0.2605681690453994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}