{"id":"W4309245369","doi":"10.1002/cbic.202200564","title":"Salt‐Toggled Capture Selection of Uric Acid Binding Aptamers","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; Hypoxanthine; Uric acid; Isothermal titration calorimetry; Chemistry; Biochemistry; Xanthine; Rasburicase; Combinatorial chemistry; Systematic evolution of ligands by exponential enrichment; Enzyme; Molecular biology; Biology; RNA; Hyperuricemia; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001664633,0.0001506074,0.0001779948,0.00008781289,0.0001541328,0.000007314054,0.0001719371,0.0001052485,0.00002511029],"category_scores_gemma":[0.00004474944,0.0001527458,0.000152808,0.0003765562,0.00007112649,0.000002433649,0.000166266,0.0001563329,0.000001306891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004746658,"about_ca_system_score_gemma":0.00005151216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008854637,"about_ca_topic_score_gemma":0.000003703361,"domain_scores_codex":[0.9990175,0.00004203803,0.0002031983,0.0003480637,0.0001803943,0.0002087403],"domain_scores_gemma":[0.9994527,0.000004873829,0.000164434,0.0002526099,0.00007595864,0.00004945434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005507205,0.00006076974,0.0004309796,0.00001335407,0.00006006566,0.000001171448,0.00002681145,0.000006422339,0.9963468,0.00001365636,0.002038979,0.0009459189],"study_design_scores_gemma":[0.0002156713,0.0001607136,0.0000484847,0.000004829441,0.00003634368,0.0000280363,0.0002596565,0.00003466038,0.9915207,0.00002188056,0.00748597,0.0001830554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979945,0.0002884079,0.0004709495,0.00008553804,0.0000673121,0.0001045402,0.00002694656,0.00005132155,0.0009104715],"genre_scores_gemma":[0.996294,0.00004936083,0.001925504,0.0001299702,0.00008755489,0.00001904681,0.0002569108,0.00002306366,0.001214655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00544699,"threshold_uncertainty_score":0.6228791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006752047320940032,"score_gpt":0.2420264502417615,"score_spread":0.2352744029208214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}