{"id":"W4309245369","doi":"10.1002/cbic.202200564","title":"Salt‐Toggled Capture Selection of Uric Acid Binding Aptamers","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; Hypoxanthine; Uric acid; Isothermal titration calorimetry; Chemistry; Biochemistry; Xanthine; Rasburicase; Combinatorial chemistry; Systematic evolution of ligands by exponential enrichment; Enzyme; Molecular biology; Biology; RNA; Hyperuricemia; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003030916,0.0005220136,0.0003949668,0.0002393535,0.0001449066,0.0003439994,0.000356434,0.0004835344,0.0006664174],"category_scores_gemma":[0.0005447188,0.0002271256,0.000229319,0.0002171801,0.0002061161,0.0002163144,0.0003378591,0.0003973375,0.0003895366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882366,"about_ca_system_score_gemma":0.0001178187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003549508,"about_ca_topic_score_gemma":0.0006149318,"domain_scores_codex":[0.9995624,0.00009673373,0.00003807641,0.0001216573,0.0001271632,0.00005391216],"domain_scores_gemma":[0.9997643,0.0000494107,0.00005931213,0.00002920318,0.0000582648,0.00003943702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001586549,0.000009509786,0.000051489,0.00001128127,0.000002858631,0.00001242486,0.00001129209,0.0001031265,0.9988804,0.00002039678,0.0000165257,0.0008647973],"study_design_scores_gemma":[0.000002581199,0.00006079781,0.0002692814,9.546111e-7,0.000003282698,0.00003123181,0.000003386728,0.0008404165,0.9984578,0.0000082929,0.0003169783,0.000004857208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694465,0.0005073902,0.02861676,0.00006891247,0.00005230873,0.0001082267,0.0001652966,0.000288148,0.0007463365],"genre_scores_gemma":[0.965075,0.0002299033,0.03138956,0.0001086565,0.00001191922,0.0000811163,0.0002581748,0.00006867843,0.002776997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006664174,"threshold_uncertainty_score":0.002229333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006752047320940032,"score_gpt":0.2420264502417615,"score_spread":0.2352744029208214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}