{"id":"W4309245457","doi":"10.1177/09636897221136149","title":"CD8 T Cells Target Antigen Cross-Presented by Bone Marrow Derived Cells to Induce Bystander Rejection of Grafts Lacking the Cognate Peptide-MHC","year":2022,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; CD8; MHC class I; Cross-presentation; Major histocompatibility complex; Antigen presentation; Immunology; Biology; Antigen; Antigen-presenting cell; T cell; Bone marrow; Cell biology; Immune system; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005224477,0.0002197597,0.0002662147,0.0001539083,0.0007940021,0.00003007962,0.0002992797,0.0001413739,0.0007554319],"category_scores_gemma":[0.000009754369,0.0001954048,0.0001277703,0.000328028,0.0001493633,0.0001351688,0.00003954869,0.0003830561,0.00006913151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005307536,"about_ca_system_score_gemma":0.00006349356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002977241,"about_ca_topic_score_gemma":0.00002182086,"domain_scores_codex":[0.9979867,0.0007558595,0.0004643573,0.0003241547,0.0001030671,0.000365903],"domain_scores_gemma":[0.9990956,0.0002837243,0.000232037,0.0002819049,0.00008744853,0.00001926771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002614273,0.0001535306,0.0005679819,0.00007521579,0.0001062901,0.000006337614,0.00503176,0.001107996,0.9871671,0.000005121678,0.002960552,0.000203794],"study_design_scores_gemma":[0.001837449,0.0002777985,0.002823773,0.00003432443,0.00004835486,0.00003611512,0.0009968516,0.00001001946,0.9650744,0.00001614889,0.02862741,0.0002173333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901397,0.004600385,0.002649627,0.0001383232,0.001025544,0.0006242494,0.0003932635,0.00005845972,0.000370396],"genre_scores_gemma":[0.9939307,0.001439507,0.00005510313,0.000274102,0.00001269586,0.00006859987,0.0006236549,0.00003539149,0.003560252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02566686,"threshold_uncertainty_score":0.827145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076518188966524,"score_gpt":0.2392664534309341,"score_spread":0.2285012715412689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}