{"id":"W4309245457","doi":"10.1177/09636897221136149","title":"CD8 T Cells Target Antigen Cross-Presented by Bone Marrow Derived Cells to Induce Bystander Rejection of Grafts Lacking the Cognate Peptide-MHC","year":2022,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; CD8; MHC class I; Cross-presentation; Major histocompatibility complex; Antigen presentation; Immunology; Biology; Antigen; Antigen-presenting cell; T cell; Bone marrow; Cell biology; Immune system; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009770237,0.000595093,0.0003021337,0.0002037609,0.0001006619,0.0002858835,0.0001717283,0.0005528966,0.00335142],"category_scores_gemma":[0.0001031118,0.000127279,0.0002312009,0.00007962532,0.0001796773,0.0001928745,0.0003003688,0.001093861,0.0009013432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001219403,"about_ca_system_score_gemma":0.00009824347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000682036,"about_ca_topic_score_gemma":0.0001075996,"domain_scores_codex":[0.9998587,0.00001987507,0.000008675011,0.00003735396,0.00002608252,0.0000492662],"domain_scores_gemma":[0.9999403,0.00001608586,0.00001324194,0.000007688534,0.000006310336,0.00001637081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005257505,0.00005600387,0.0001703745,0.00005995093,0.000004796342,0.00006460573,0.00001424798,0.00005867012,0.9960604,0.0001133926,0.0000483394,0.00329656],"study_design_scores_gemma":[0.0001106449,0.001947106,0.002970753,0.00003802413,0.00004182148,0.0008349655,0.00004771373,0.001746445,0.9859306,0.0004193784,0.005906813,0.000005833146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837611,0.002431706,0.008433425,0.0001331981,0.0001286973,0.00009691984,0.00006385394,0.0002128524,0.004738256],"genre_scores_gemma":[0.9905798,0.001034868,0.003387632,0.000140277,0.00006299125,0.00006648699,0.000104354,0.00002442866,0.004599349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335142,"threshold_uncertainty_score":0.01121163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076518188966524,"score_gpt":0.2392664534309341,"score_spread":0.2285012715412689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}