{"id":"W4309246311","doi":"10.1002/cam4.5421","title":"Molecular characterization of <scp>AML‐MRC</scp> reveals <scp><i>TP53</i></scp> mutation as an adverse prognostic factor irrespective of <scp>MRC</scp>‐defining criteria, <scp><i>TP53</i></scp> allelic state, or <scp><i>TP53</i></scp> variant allele frequency","year":2022,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Leukemia and Lymphoma Research; Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Neuroblastoma RAS viral oncogene homolog; Allele; Myeloid leukemia; Internal medicine; Medicine; Oncology; Mutation; Cancer research; Biology; Genetics; Cancer; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002240848,0.000154885,0.0001775563,0.001190671,0.0001770074,0.0003817329,0.0002378853,0.0002231862,0.001335917],"category_scores_gemma":[0.0007832869,0.00008987247,0.0001888158,0.000567233,0.0002537053,0.0001965961,0.0002129643,0.0001890505,0.0002489756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437919,"about_ca_system_score_gemma":0.0002138476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002223715,"about_ca_topic_score_gemma":0.002283532,"domain_scores_codex":[0.9998605,0.00001377977,0.00002500483,0.00003366934,0.00003399706,0.0000330414],"domain_scores_gemma":[0.9992974,0.0001450364,0.0002909862,0.00004576765,0.0000886555,0.0001321258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002506291,0.00001479692,0.9735504,0.00002104474,0.00001901296,0.00164987,0.00003543657,0.0002767405,0.01828357,0.00007929149,0.0001701093,0.005649026],"study_design_scores_gemma":[0.000009152606,0.0001280258,0.9823104,0.00000950089,0.00003280435,0.008347328,0.0001106138,0.001265244,0.006951674,0.00007186391,0.0007586106,0.000004775439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985684,0.0001789377,0.0001931049,0.00002157999,0.000002002876,0.000009082381,0.0003686398,0.00001161077,0.0006465917],"genre_scores_gemma":[0.9993123,0.00005771645,0.0001951765,0.000007256397,0.000004015668,0.000003652164,0.000345181,0.000001764125,0.00007292509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223715,"threshold_uncertainty_score":0.004469097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322975246219321,"score_gpt":0.3145920525268237,"score_spread":0.2913623000646304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}