{"id":"W4309246446","doi":"10.1007/s00204-022-03410-2","title":"Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture","year":2022,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Università degli Studi di Milano","keywords":"Craniofacial; Embryo; Teratology; Pharmacology; Potency; Fluconazole; Pregnancy; Developmental toxicity; Morphogenesis; Fetus; In vitro; In vitro fertilisation; Drug; Medicine; Biology; Toxicology; Antifungal; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283305,0.0001661231,0.0004794218,0.00009561014,0.000331324,0.000008354928,0.000155738,0.00004280432,0.00001734256],"category_scores_gemma":[0.0001595328,0.0000842446,0.00009499236,0.00013058,0.0006950311,0.00005124471,0.000330726,0.0005625441,3.266203e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003496404,"about_ca_system_score_gemma":0.00002625907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000127114,"about_ca_topic_score_gemma":0.00003214009,"domain_scores_codex":[0.9979345,0.000980534,0.0003889795,0.0002577423,0.0001792107,0.0002591022],"domain_scores_gemma":[0.998894,0.000719308,0.0001836968,0.0001517622,0.00001495508,0.00003631942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002953768,0.0005936143,0.03950455,0.0001796971,0.0001110027,0.00001644663,0.00560103,0.0004179024,0.9485742,0.0001611547,0.00003744527,0.001849206],"study_design_scores_gemma":[0.02170509,0.0009697013,0.7480654,0.0003145818,0.0003319833,0.0001081265,0.001776107,0.01684342,0.2077068,0.0019568,0.00002110136,0.0002009725],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952027,0.002050362,0.00001934011,0.001136141,0.00009995025,0.001251178,0.00007212715,0.00001417363,0.0001540101],"genre_scores_gemma":[0.9987733,0.0005936875,0.0000132609,0.0002409584,0.00003064415,0.0002471896,0.00001892896,0.000009189352,0.00007282734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7408674,"threshold_uncertainty_score":0.3435395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363917890061278,"score_gpt":0.2694623245421005,"score_spread":0.2558231456414877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}