{"id":"W4309261606","doi":"10.1101/2022.11.17.516819","title":"Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; Agence Nationale de la Recherche; Michael Smith Health Research BC","keywords":"Perilipin; Diacylglycerol kinase; Phosphatidic acid; Endoplasmic reticulum; Membrane contact site; Phospholipid; Membrane; Cell biology; Endosome; Lipid droplet; Organelle; Biology; Chemistry; Biochemistry; Membrane protein; Integral membrane protein; Intracellular; Signal transduction; Lipolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023598,0.000136539,0.0001029318,0.0001003642,0.0001603963,0.0002181586,0.000129564,0.0002630125,0.001394291],"category_scores_gemma":[0.00009942284,0.0001063213,0.0001375022,0.00009893881,0.0001705171,0.0001874416,0.0002050005,0.0004609035,0.0004219068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003710583,"about_ca_system_score_gemma":0.00009513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028488,"about_ca_topic_score_gemma":0.0005495559,"domain_scores_codex":[0.9999589,0.000004923757,0.000001745067,0.000009966953,0.00001237624,0.00001207001],"domain_scores_gemma":[0.9999467,0.000009908235,0.00001672717,0.00000438799,0.000005187231,0.0000170474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001367892,0.00001201084,0.0004684526,0.00002326555,0.000003151858,0.0001656603,0.00002300535,0.0002131389,0.9982899,0.0001246173,0.00007176613,0.0004682899],"study_design_scores_gemma":[0.00003977567,0.00009276193,0.02666032,0.00001200005,0.00001150957,0.0005386,0.0001359766,0.009446118,0.9589949,0.0004484395,0.003605996,0.0000135374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965571,0.0004237249,0.001557314,0.0001988653,0.00002186143,0.000006928627,0.0001870639,0.00005538513,0.0009918452],"genre_scores_gemma":[0.9969121,0.0002263889,0.00121708,0.0001200461,0.00000591161,0.000006748619,0.0003050035,0.00001676846,0.001189894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394291,"threshold_uncertainty_score":0.004664421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207708661362634,"score_gpt":0.2431333898137857,"score_spread":0.2310563032001594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}