{"id":"W4309263961","doi":"10.1101/2022.11.16.516773","title":"Germline determinants of the prostate tumor genome","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Vector Institute; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Health and Medical Research Council; Norges Forskningsråd; Prostate Cancer Canada; Prostate Cancer Foundation; Movember Foundation; Helse Sør-Øst RHF; Medical Research Council; Cancer Prevention and Research Institute of Texas; Instituto Tecnológico de Costa Rica; Cancer Association of South Africa; Universitetet i Oslo; Genome Canada; National Institutes of Health; U.S. Department of Defense","keywords":"Germline; Biology; Genetics; Genome; Prostate cancer; Germline mutation; Somatic cell; Transcriptome; Gene; Computational biology; Cancer; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002590582,0.0001060054,0.0001767045,0.0006255112,0.0001489729,0.0004099657,0.0001074035,0.0001374551,0.001625262],"category_scores_gemma":[0.0008992498,0.0001016916,0.0001705855,0.0008088193,0.0001917066,0.0001445377,0.0002919846,0.0001964241,0.0001800843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001814084,"about_ca_system_score_gemma":0.0001347901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00176899,"about_ca_topic_score_gemma":0.001979143,"domain_scores_codex":[0.9997503,0.00003357371,0.000009138895,0.0001064421,0.00006650029,0.00003395175],"domain_scores_gemma":[0.9996071,0.0001242514,0.0001527394,0.00004525969,0.00003612308,0.00003454424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002534338,0.00003058533,0.6940705,0.0001126723,0.0002657627,0.0002803526,0.0001969593,0.0038528,0.2670307,0.002215923,0.0005824768,0.03110789],"study_design_scores_gemma":[0.000006271171,0.00005421786,0.9688305,0.000008358353,0.00006937507,0.0006925467,0.00009100883,0.004632885,0.02228607,0.001452697,0.001865015,0.00001111231],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942773,0.0004519282,0.003034565,0.00004037915,0.000003318083,0.000003442005,0.001239356,0.00005520902,0.0008944757],"genre_scores_gemma":[0.9985618,0.00006660424,0.0007555073,0.00001283903,0.000003145566,0.000001466867,0.0004554972,0.000008906544,0.0001342774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00176899,"threshold_uncertainty_score":0.005437076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211974473910733,"score_gpt":0.2725880257396122,"score_spread":0.2513905783485389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}