{"id":"W4309269409","doi":"10.3390/ijms232214142","title":"Simultaneous Inhibition of Histone Deacetylases and RNA Synthesis Enables Totipotency Reprogramming in Pig SCNT Embryos","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Somatic cell nuclear transfer; Reprogramming; Biology; Chromatin; Histone; Cell biology; Blastocyst; Histone deacetylase; Somatic cell; Embryo; Molecular biology; Genetics; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841019,0.0003121658,0.0003091543,0.0001255181,0.00008966686,0.0002664393,0.0001513049,0.0002622806,0.0006085624],"category_scores_gemma":[0.0001334857,0.0001402089,0.0003372309,0.00007039349,0.0001802375,0.0001459424,0.0001694502,0.0003829618,0.0002617687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760418,"about_ca_system_score_gemma":0.0001765218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231578,"about_ca_topic_score_gemma":0.000693782,"domain_scores_codex":[0.9998531,0.00002077052,0.00001972496,0.00004289963,0.00003836234,0.00002512517],"domain_scores_gemma":[0.9999189,0.00002552687,0.00002722197,0.00000962,0.000007362234,0.00001139221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000178935,0.000004213536,0.00004244516,0.00001773578,0.000001635464,0.00001356175,0.000004532451,0.00002533789,0.9993626,0.00002063828,0.000005166896,0.0004840987],"study_design_scores_gemma":[0.000005570689,0.0002847363,0.001950942,0.000005123875,0.00001422192,0.000081543,0.00000734754,0.0004541477,0.9952934,0.00001814151,0.001880968,0.000003789092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806026,0.004730578,0.01082954,0.00009790568,0.0001112626,0.0000782934,0.0004484253,0.0001131345,0.002988267],"genre_scores_gemma":[0.9860535,0.002970208,0.006702346,0.00009050985,0.00002579068,0.00007130195,0.0007514408,0.00004205889,0.003292791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006085624,"threshold_uncertainty_score":0.002035856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00722407009593315,"score_gpt":0.3035455343156614,"score_spread":0.2963214642197283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}