{"id":"W4309269409","doi":"10.3390/ijms232214142","title":"Simultaneous Inhibition of Histone Deacetylases and RNA Synthesis Enables Totipotency Reprogramming in Pig SCNT Embryos","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Somatic cell nuclear transfer; Reprogramming; Biology; Chromatin; Histone; Cell biology; Blastocyst; Histone deacetylase; Somatic cell; Embryo; Molecular biology; Genetics; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004833557,0.00006516089,0.00009980021,0.000177043,0.00004595505,0.00002041044,0.0002170873,0.00002178893,0.00001217396],"category_scores_gemma":[0.0003401957,0.0000633336,0.00005876015,0.0001071948,0.00009597945,0.000007904679,0.0001274373,0.00007095584,8.434321e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002749892,"about_ca_system_score_gemma":0.00007256922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003358481,"about_ca_topic_score_gemma":0.000009958413,"domain_scores_codex":[0.9990531,0.00004739983,0.000282273,0.000142544,0.000378349,0.00009636277],"domain_scores_gemma":[0.9995801,0.00004144622,0.0001717892,0.00006203153,0.0001122478,0.00003236965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004202764,0.00006101012,0.0005507389,0.00000633239,0.00002639239,0.0001273305,0.0001010722,0.05854589,0.9212831,0.00006836105,0.0000129471,0.01917482],"study_design_scores_gemma":[0.0002993814,0.0003960303,0.000477943,0.0000522675,0.00001269444,0.000431408,0.0006942251,0.001364649,0.9951226,0.0001866189,0.0008573972,0.0001048428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902787,0.003563583,0.005617403,0.0002079609,0.000179545,0.00004131901,0.000004892383,0.000001608674,0.0001049446],"genre_scores_gemma":[0.9969285,0.0002211346,0.002741038,0.00004447901,0.00004060717,0.000004018555,0.000001679495,0.000004855725,0.00001367859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07383947,"threshold_uncertainty_score":0.2582669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00722407009593315,"score_gpt":0.3035455343156614,"score_spread":0.2963214642197283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}