{"id":"W4309277379","doi":"10.1002/jcsm.13121","title":"Activation of <scp>eIF4E</scp>‐binding‐protein‐1 rescues <scp>mTORC1</scp>‐induced sarcopenia by expanding lysosomal degradation capacity","year":2022,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; National University Health System; China Medical University; National University of Singapore; National Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Sarcopenia; mTORC1; Medicine; EIF4E; Degradation (telecommunications); Protein degradation; Cell biology; Phosphorylation; Biochemistry; Messenger RNA; Endocrinology; Gene; Chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007186859,0.0002653547,0.0004347095,0.0001772267,0.0004111758,0.00004467588,0.0003697909,0.0002001964,0.00003099953],"category_scores_gemma":[0.0005750639,0.0002605842,0.0002016147,0.0002337277,0.0001276753,0.00007359394,0.0002438184,0.0004404195,0.000002010061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006488062,"about_ca_system_score_gemma":0.0001870739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008289539,"about_ca_topic_score_gemma":0.00001379293,"domain_scores_codex":[0.9978697,0.0003491008,0.0006293323,0.0003672726,0.0004128059,0.0003718189],"domain_scores_gemma":[0.9984128,0.000127862,0.0008144257,0.0002767985,0.0001933687,0.0001747765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198032,0.000191185,0.001436179,0.000043847,0.0001215729,0.000003062917,0.0004468268,0.00005728747,0.9891678,0.00007703879,0.006258764,0.002076651],"study_design_scores_gemma":[0.002155157,0.001420324,0.009046209,0.00005235111,0.00007758741,0.0000431498,0.002624461,0.0000267548,0.9662462,0.000342907,0.01785427,0.0001105908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997468,0.0008010394,0.0003048788,0.00009639977,0.0001894767,0.000297644,0.00004769067,0.000009751794,0.0007851138],"genre_scores_gemma":[0.9983609,0.0001380095,0.0003745825,0.0001363906,0.0001747261,0.00002714845,0.0001137252,0.00003638695,0.0006381487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02292154,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709566461300734,"score_gpt":0.2464443397807358,"score_spread":0.2293486751677284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}