{"id":"W4309277379","doi":"10.1002/jcsm.13121","title":"Activation of <scp>eIF4E</scp>‐binding‐protein‐1 rescues <scp>mTORC1</scp>‐induced sarcopenia by expanding lysosomal degradation capacity","year":2022,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; National University Health System; China Medical University; National University of Singapore; National Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Sarcopenia; mTORC1; Medicine; EIF4E; Degradation (telecommunications); Protein degradation; Cell biology; Phosphorylation; Biochemistry; Messenger RNA; Endocrinology; Gene; Chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791074,0.0005968835,0.0005430474,0.0004834256,0.0003169783,0.0003378787,0.0004655513,0.000571694,0.003204886],"category_scores_gemma":[0.0000881093,0.0002661953,0.0004844666,0.0003391946,0.0005845331,0.0002046577,0.0003108798,0.0009687712,0.001100321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006318947,"about_ca_system_score_gemma":0.0006252463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001390894,"about_ca_topic_score_gemma":0.002564729,"domain_scores_codex":[0.9997516,0.00002018243,0.00003818173,0.00006007482,0.00006708743,0.00006291214],"domain_scores_gemma":[0.9997945,0.0000223206,0.00008511233,0.00001847723,0.00001523088,0.00006431849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775822,0.00004878818,0.00009110478,0.00007769727,0.000009475626,0.00003927249,0.000008723605,0.00009534451,0.9984515,0.0001193589,0.0001902544,0.000690867],"study_design_scores_gemma":[0.00005360851,0.0002160712,0.002045449,0.00001022155,0.00001829481,0.0001596674,0.00001758645,0.0007599042,0.9921637,0.00003619455,0.004512372,0.000006973978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982579,0.002079424,0.006176703,0.0004336786,0.0001532298,0.0001182316,0.004351909,0.0008929864,0.003214964],"genre_scores_gemma":[0.9733239,0.001852305,0.008030653,0.000199179,0.00003971971,0.0003057133,0.005249867,0.0003025281,0.01069619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204886,"threshold_uncertainty_score":0.01072139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709566461300734,"score_gpt":0.2464443397807358,"score_spread":0.2293486751677284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}