{"id":"W4309278693","doi":"10.1016/j.biomaterials.2022.121918","title":"Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy","year":2022,"lang":"en","type":"article","venue":"Biomaterials","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Toronto General Hospital; Princess Margaret Cancer Centre; McMaster University","funders":"Terry Fox Research Institute","keywords":"Photodynamic therapy; Immune system; Cancer research; Abscopal effect; Immune checkpoint; CD80; Innate immune system; Immunotherapy; Immunology; Dendritic cell; Medicine; Cytotoxic T cell; Biology; Chemistry; CD40","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278092,0.0004317278,0.0003577278,0.0002189935,0.0002173935,0.0003874419,0.0002944514,0.0004875011,0.002445021],"category_scores_gemma":[0.0001899982,0.0001465302,0.0005018988,0.0001356247,0.0003744751,0.0004816577,0.000241381,0.0009184863,0.0004361477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706915,"about_ca_system_score_gemma":0.0004885596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004696744,"about_ca_topic_score_gemma":0.0007888261,"domain_scores_codex":[0.9997403,0.0000504913,0.00001303598,0.00004400772,0.0000500207,0.0001021389],"domain_scores_gemma":[0.9998869,0.00002192977,0.00002535701,0.00002796937,0.00001196723,0.00002595566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008436242,0.0002825065,0.0001758112,0.00007663845,0.00001277735,0.00005642462,0.00001956323,0.00006553209,0.9935012,0.000476135,0.0000938755,0.004395848],"study_design_scores_gemma":[0.0000840119,0.002034137,0.00253103,0.00001082065,0.00003617676,0.0002302716,0.00004203274,0.000469216,0.9928039,0.0001185886,0.001634039,0.000005735244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903122,0.004276078,0.002725852,0.0001198936,0.00007613491,0.00007724888,0.00005636593,0.00007942043,0.002276815],"genre_scores_gemma":[0.9952174,0.0009265804,0.001249427,0.00004851171,0.00002661246,0.00004522652,0.00006379293,0.000009803574,0.00241263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002445021,"threshold_uncertainty_score":0.008179367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294920289937425,"score_gpt":0.3045836666719393,"score_spread":0.281634463772565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}