{"id":"W4309281484","doi":"10.1007/s12035-022-03121-w","title":"Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells","year":2022,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Montreal Neurological Institute and Hospital; Centre hospitalier universitaire de Québec; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"FLNA; Filamin; Tauopathy; Cell biology; Microtubule; Tau protein; Biology; Phosphorylation; Proximity ligation assay; Actin; Cytoskeleton; Neuroscience; Chemistry; Neurodegeneration; Alzheimer's disease; Pathology; Cell; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329074,0.0005365719,0.0002761045,0.0002388619,0.000304053,0.0004418681,0.000276595,0.0005930439,0.001451385],"category_scores_gemma":[0.0001310372,0.0001138337,0.0004964477,0.0001759278,0.0002909942,0.0004490977,0.0004431762,0.0005896664,0.0005332677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005177542,"about_ca_system_score_gemma":0.0002457668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002245245,"about_ca_topic_score_gemma":0.002515946,"domain_scores_codex":[0.9998052,0.00003457547,0.00001718997,0.00003916756,0.00004772771,0.00005623452],"domain_scores_gemma":[0.9998908,0.00002728473,0.00001917863,0.00002121683,0.00001699716,0.0000244329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001828779,0.00003491677,0.0001877377,0.0001019152,0.000016373,0.0001934202,0.00002877074,0.00004333172,0.9976962,0.0001073537,0.00003016661,0.001376837],"study_design_scores_gemma":[0.00003327562,0.0005325722,0.0115841,0.00002172905,0.00006686854,0.0003916826,0.000118681,0.0006494294,0.9829566,0.00008829418,0.003546202,0.00001046527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885971,0.004902437,0.001669138,0.0001235424,0.00006209664,0.00003574534,0.0004753518,0.00004803452,0.004086606],"genre_scores_gemma":[0.9928513,0.002329018,0.001173461,0.00007031792,0.00002159302,0.00004320873,0.0004125521,0.000007821504,0.003090879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245245,"threshold_uncertainty_score":0.004855335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856142924920376,"score_gpt":0.2542908316281477,"score_spread":0.2457294023789439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}