{"id":"W4309284636","doi":"10.26434/chemrxiv-2022-b8pdw","title":"Oxidation-controlled, Strain-Promoted Tellurophene-Alkyne Cycloaddition (OSTAC): A Bioorthogonal Reaction for Fast and Selective Protein Conjugation","year":2022,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Faculty of Arts and Sciences; University of Alberta; University of Toronto; McMaster University","keywords":"Bioorthogonal chemistry; Cycloaddition; Chemistry; Alkyne; Azide; Combinatorial chemistry; Click chemistry; Chemical synthesis; Stereochemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875061,0.0004799405,0.0001833456,0.0001695564,0.0001319361,0.0002411785,0.000283983,0.0003739781,0.0005648701],"category_scores_gemma":[0.0001346579,0.0001630968,0.0002064676,0.0001787895,0.000303814,0.0003047888,0.0003235602,0.0004869326,0.0002847592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468904,"about_ca_system_score_gemma":0.0002395836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002716512,"about_ca_topic_score_gemma":0.0005652154,"domain_scores_codex":[0.9998665,0.00001960246,0.000008051021,0.00003723813,0.00003879182,0.00002979462],"domain_scores_gemma":[0.9999295,0.00001553212,0.00002558048,0.00001051438,0.000008794701,0.000009990529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002000312,0.00001101649,0.00005061099,0.00004765939,0.000004486291,0.00006166595,0.00002000746,0.0001099052,0.9959556,0.0004450016,0.00009252937,0.003181593],"study_design_scores_gemma":[0.000003545494,0.00006733804,0.0001604914,0.000001316926,0.000003961766,0.0001345296,0.000005198676,0.000587171,0.9969912,0.00003568338,0.002005543,0.000004050178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8702782,0.003873886,0.1175811,0.0003927428,0.0001487636,0.0001987458,0.0002786377,0.0004743179,0.006773603],"genre_scores_gemma":[0.957941,0.002474053,0.03460069,0.0001011356,0.00002813417,0.00007763191,0.0002067661,0.00004062525,0.004530027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005648701,"threshold_uncertainty_score":0.001889706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677486089752043,"score_gpt":0.2589433188584912,"score_spread":0.2421684579609708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}