{"id":"W4309305948","doi":"10.1093/nar/gkac1049","title":"MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":453,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Simon Fraser University; University of Manitoba","funders":"National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; Fundação para a Ciência e a Tecnologia; Danmarks Grundforskningsfond; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; National Research Foundation of Korea; Cooperative Research Centres, Australian Government Department of Industry; University of Strathclyde; U.S. Department of Energy; European Commission; Deutsche Forschungsgemeinschaft; National Research Foundation; National Science Foundation; UK Research and Innovation; Government of the United Kingdom; Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional; Novo Nordisk Fonden; Netherlands eScience Center; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Consejo Nacional de Ciencia y Tecnología; National Institute of General Medical Sciences; Novo Nordisk","keywords":"Biology; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009028582,0.003356108,0.003533694,0.01634116,0.002297577,0.005679852,0.006403272,0.002915559,0.0129171],"category_scores_gemma":[0.02285555,0.002063925,0.002822418,0.01303154,0.001274058,0.004581926,0.01115095,0.003835591,0.01732908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002192647,"about_ca_system_score_gemma":0.006746447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005696587,"about_ca_topic_score_gemma":0.008202374,"domain_scores_codex":[0.9946427,0.0008670989,0.0009735592,0.001511953,0.001593196,0.000411385],"domain_scores_gemma":[0.988987,0.002872985,0.00173344,0.002966061,0.002134582,0.001305778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006159435,0.0008529314,0.02852171,0.01930551,0.001495607,0.001679804,0.003721116,0.00747147,0.1403454,0.02190323,0.6340042,0.1345395],"study_design_scores_gemma":[0.0005376422,0.0004957084,0.02190117,0.001360744,0.0005347885,0.001251056,0.0007369644,0.00819588,0.0316702,0.009116765,0.9237728,0.0004262829],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"software","genre_scores_codex":[0.02961304,0.002723766,0.0397564,0.0006132108,0.0004120536,0.0007191848,0.8761566,0.04107374,0.008931994],"genre_scores_gemma":[0.006502997,0.0005115581,0.03814448,0.0002013311,0.00002150733,0.000663096,0.9509811,0.002127178,0.0008467662],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.01634116,"threshold_uncertainty_score":0.04774827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07228368222249668,"score_gpt":0.3564222768261625,"score_spread":0.2841385946036658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}