{"id":"W4309307116","doi":"10.3390/app122211623","title":"Simvastatin Embedded into Poly(Lactic-Co-Glycolic Acid)-Based Scaffolds in Promoting Preclinical Bone Regeneration: A Systematic Review","year":2022,"lang":"en","type":"review","venue":"Applied Sciences","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Simvastatin; Glycolic acid; Calvaria; Medicine; PLGA; Scaffold; Bone formation; Biomedical engineering; Pharmacology; Lactic acid; Internal medicine; Chemistry; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004503281,0.001200345,0.005960552,0.009231971,0.0004932405,0.002074261,0.00139392,0.001600279,0.003596786],"category_scores_gemma":[0.01141587,0.0006359587,0.00540659,0.007728064,0.0007035308,0.001551482,0.001026926,0.0005660936,0.0003607589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001723579,"about_ca_system_score_gemma":0.007682822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004024156,"about_ca_topic_score_gemma":0.01154032,"domain_scores_codex":[0.9971876,0.0007399899,0.001203796,0.0002300162,0.0005476002,0.00009089102],"domain_scores_gemma":[0.9898455,0.006884147,0.001910603,0.0001507596,0.001054836,0.0001541809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002022949,0.00002187351,0.0003301575,0.941115,0.003586703,0.00007467913,0.00009683442,0.00007733946,0.0003965791,0.0001554797,0.0008619255,0.0530812],"study_design_scores_gemma":[0.0002978672,0.0005957609,0.003765614,0.8692381,0.08293186,0.0006392367,0.0002720077,0.0001746665,0.0008051693,0.0003616282,0.04086585,0.00005219157],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007451748,0.9985936,0.0001119011,0.0001133986,0.0000520428,0.0001199331,0.0001181504,0.000005334562,0.000140561],"genre_scores_gemma":[0.005819188,0.9931772,0.0003705946,0.000207641,0.0000488476,0.0001925702,0.00009327632,0.000003025841,0.00008772917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009231971,"threshold_uncertainty_score":0.02381593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08228006474605494,"score_gpt":0.3967518564633382,"score_spread":0.3144717917172832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}