{"id":"W4309308048","doi":"10.3390/pharmaceutics14112463","title":"Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Nanocarriers; Nanotoxicology; Commercialization; Nanotechnology; Drug delivery; Risk analysis (engineering); Drug; Biochemical engineering; Medicine; Pharmacology; Business; Engineering; Nanoparticle; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001238281,0.0002673328,0.0008555619,0.0004009258,0.0002341435,0.00001966711,0.0002822989,0.00009038734,0.0001075238],"category_scores_gemma":[0.00005294781,0.0002572641,0.00009544458,0.0004453351,0.0001436358,0.00008138898,0.0002387495,0.0002076514,0.000003339278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573349,"about_ca_system_score_gemma":0.0002768695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006882785,"about_ca_topic_score_gemma":0.0001019005,"domain_scores_codex":[0.9976594,0.000262763,0.0009986042,0.0006084983,0.0001620453,0.0003086464],"domain_scores_gemma":[0.997928,0.001209165,0.0004282832,0.0002700085,0.00004806869,0.0001164702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004428391,0.0002892905,0.0000216987,0.001947895,0.00001449945,9.536014e-8,0.0002988917,0.000007289452,0.002582985,0.0008689708,0.00003067186,0.9938934],"study_design_scores_gemma":[0.0008211844,0.000007375474,0.0001153999,0.0003472723,0.0001455617,0.000004178202,0.0000677349,0.0000959219,0.003299765,0.0001562518,0.9946992,0.0002401965],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002912237,0.9939023,0.000155716,0.0002627228,0.000130125,0.001956399,0.000577349,0.00002670602,0.00007648421],"genre_scores_gemma":[0.002931236,0.9900103,0.001525593,0.00001331221,0.00002974736,0.005325051,0.0001082494,0.00002771068,0.00002886431],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946685,"threshold_uncertainty_score":0.999988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1611880571253872,"score_gpt":0.3918540635990325,"score_spread":0.2306660064736452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}