{"id":"W4309308048","doi":"10.3390/pharmaceutics14112463","title":"Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Nanocarriers; Nanotoxicology; Commercialization; Nanotechnology; Drug delivery; Risk analysis (engineering); Drug; Biochemical engineering; Medicine; Pharmacology; Business; Engineering; Nanoparticle; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006492823,0.0007204109,0.001181787,0.0019387,0.0007716075,0.003265636,0.001074998,0.002744675,0.00239833],"category_scores_gemma":[0.003130967,0.0005737902,0.0007242471,0.001663118,0.002719282,0.005353423,0.002255666,0.003849462,0.001149585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001723699,"about_ca_system_score_gemma":0.001698288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009917128,"about_ca_topic_score_gemma":0.001561626,"domain_scores_codex":[0.997656,0.0007504862,0.0002209273,0.000350956,0.0008746065,0.0001469594],"domain_scores_gemma":[0.9952796,0.003232545,0.0004022153,0.0001666331,0.0007672634,0.0001517805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001473068,0.0001910999,0.001598248,0.01208201,0.00007207754,0.000585591,0.001104297,0.002606349,0.03201645,0.1059863,0.01339572,0.8302146],"study_design_scores_gemma":[0.00002379151,0.0006998596,0.001316697,0.003908251,0.00009061594,0.00254805,0.001127547,0.002559411,0.025236,0.04673973,0.9156153,0.000134869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002276278,0.9795536,0.007998219,0.005629685,0.0003338064,0.00002089308,0.00002155174,0.00003585137,0.004130115],"genre_scores_gemma":[0.02031013,0.9615754,0.01265852,0.002360607,0.001091946,0.00005551071,0.00004348318,0.0000258539,0.001878565],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006492823,"threshold_uncertainty_score":0.03433776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1611880571253872,"score_gpt":0.3918540635990325,"score_spread":0.2306660064736452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}