{"id":"W4309313322","doi":"10.25251/skin.6.supp.47","title":"Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: 52-week efficacy by prior treatment in the phase 3 POETYK PSO-1 trial","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Plaque psoriasis; Medicine; Psoriasis; Internal medicine; Gastroenterology; Dermatology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009000397,0.0007628789,0.001742347,0.0001885738,0.000377236,0.000906942,0.0004580011,0.0009186915,0.005712518],"category_scores_gemma":[0.0005089437,0.0002905916,0.001300632,0.0001841793,0.000398644,0.0006034786,0.0001891881,0.002262701,0.001150307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005975403,"about_ca_system_score_gemma":0.0005588647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009004535,"about_ca_topic_score_gemma":0.003460967,"domain_scores_codex":[0.9997451,0.00008637379,0.00001362177,0.00004431512,0.00003414728,0.00007649865],"domain_scores_gemma":[0.9997209,0.00005732203,0.00004260474,0.00002315447,0.00002029096,0.0001358626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6750221,0.009377876,0.002701403,0.001980606,0.002223937,0.00022132,0.0001282272,0.001702404,0.02322569,0.0004744106,0.01953187,0.2634102],"study_design_scores_gemma":[0.7883276,0.1696309,0.02215766,0.0002159973,0.001055171,0.0005986305,0.00006939683,0.001998945,0.004013636,0.0005783662,0.01128635,0.00006732107],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649587,0.01791893,0.0007773602,0.001369311,0.0005373185,0.001109491,0.002101071,0.0004276438,0.01080013],"genre_scores_gemma":[0.9817644,0.006131127,0.000646119,0.00141731,0.0002291014,0.0006749912,0.002246737,0.00004432211,0.006845889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005712518,"threshold_uncertainty_score":0.01911026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374314115538291,"score_gpt":0.2903330030110221,"score_spread":0.2665898618556392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}