{"id":"W4309318166","doi":"10.25251/skin.6.supp.63","title":"Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: correlations between patient-reported outcomes and clinical responses in the phase 3 clinical trials POETYK PSO-1 and POETYK PSO-2","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Plaque psoriasis; Medicine; Clinical trial; Psoriasis; Internal medicine; Allosteric regulation; Dermatology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601845,0.0003078156,0.0006863219,0.0002217912,0.0001406097,0.0005559815,0.0001794518,0.0003421189,0.0008618888],"category_scores_gemma":[0.00157872,0.0001254822,0.0004275459,0.0002440117,0.0001992886,0.0003892239,0.0001514725,0.0007790141,0.0001699041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081112,"about_ca_system_score_gemma":0.0002600882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003818142,"about_ca_topic_score_gemma":0.001040636,"domain_scores_codex":[0.9994239,0.0002617113,0.00004991143,0.00007516146,0.0001236358,0.00006566368],"domain_scores_gemma":[0.9987803,0.000499292,0.0003813421,0.00005331635,0.00008095112,0.0002047604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.261645,0.005899857,0.2901292,0.0008813874,0.003320072,0.0003154491,0.0001748615,0.003773446,0.06893938,0.0002109423,0.004392395,0.3603179],"study_design_scores_gemma":[0.01917841,0.08868637,0.8642011,0.00007847797,0.001581551,0.001502495,0.0001472158,0.007064541,0.01249232,0.0003243448,0.004649145,0.00009415076],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936568,0.004691974,0.0002061848,0.0001331742,0.00003143123,0.00004212771,0.000261372,0.00002703176,0.0009499204],"genre_scores_gemma":[0.9985585,0.0006090223,0.0001463427,0.00007837213,0.00002997724,0.00002014387,0.0003133325,0.000002714427,0.0002415703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001601845,"threshold_uncertainty_score":0.008471489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277193890815177,"score_gpt":0.443138186868686,"score_spread":0.3154187977871683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}