{"id":"W4309318166","doi":"10.25251/skin.6.supp.63","title":"Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: correlations between patient-reported outcomes and clinical responses in the phase 3 clinical trials POETYK PSO-1 and POETYK PSO-2","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Plaque psoriasis; Medicine; Clinical trial; Psoriasis; Internal medicine; Allosteric regulation; Dermatology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01307409,0.0003263253,0.001682509,0.0005683389,0.0003263766,0.00004054121,0.0002480042,0.0001479522,0.0001253542],"category_scores_gemma":[0.0123246,0.0001831849,0.000220781,0.0007139943,0.0002800847,0.0001618374,0.0001218091,0.002008234,0.000001293351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322106,"about_ca_system_score_gemma":0.0004335535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002627358,"about_ca_topic_score_gemma":0.0002350386,"domain_scores_codex":[0.9890253,0.005633827,0.003816496,0.0003715267,0.0008101878,0.0003426686],"domain_scores_gemma":[0.9869349,0.01038712,0.001483182,0.0004442276,0.0003592614,0.0003912806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1441282,0.01013245,0.5881659,0.0001151348,0.002649151,0.0125379,0.03744773,0.001231406,0.01022329,0.000126061,0.03353997,0.1597029],"study_design_scores_gemma":[0.127773,0.1570349,0.4539988,0.003353843,0.009321173,0.1412846,0.05200377,0.006415958,0.001313371,0.003039844,0.04267233,0.001788336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797747,0.0006368551,0.0001402072,0.0173422,0.0008111167,0.001124698,0.00008628717,0.00001696675,0.00006695044],"genre_scores_gemma":[0.9949043,0.0005229941,0.0003177338,0.003264104,0.0007943691,0.00002115273,0.00003716306,0.00003831188,0.0000999117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1579145,"threshold_uncertainty_score":0.995995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277193890815177,"score_gpt":0.443138186868686,"score_spread":0.3154187977871683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}