{"id":"W4309319238","doi":"10.25251/skin.6.supp.51","title":"Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Pooled Efficacy from Three Phase 3 Trials","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phytochemistry Medicinal Plant Applications","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"LEO Pharma; EMD Serono; Bausch Health; Sanofi Genzyme; Incyte; Castle Biosciences; Dermira; UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Helsinn; Kiniksa Pharmaceuticals; Celgene; Sanofi; Amgen; Helsinn Therapeutics; Meiji Seika Pharma; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Plaque psoriasis; Medicine; Psoriasis; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002653851,0.0001829632,0.0006764774,0.00002118101,0.0004729179,0.00001325753,0.0009240474,0.00005489413,0.001348664],"category_scores_gemma":[0.001771921,0.00005847784,0.0001905799,0.0002928409,0.0001390505,0.00004467768,0.00007339987,0.0004422478,0.000003791137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007653807,"about_ca_system_score_gemma":0.00005026087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227982,"about_ca_topic_score_gemma":0.00006692909,"domain_scores_codex":[0.9976017,0.0003128278,0.0009468663,0.000177897,0.0007063467,0.0002543252],"domain_scores_gemma":[0.9908289,0.007581535,0.001124413,0.0001323647,0.0001617883,0.0001709972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004615938,0.0005562228,0.00002271005,0.000006962078,0.0002284391,0.0001038097,0.000566561,0.0001613361,0.8719395,0.0000498501,0.05615662,0.06559203],"study_design_scores_gemma":[0.02567397,0.032189,0.001893568,0.0009076759,0.005079075,0.02038003,0.01803216,0.001447254,0.08959514,0.04600621,0.7576164,0.001179516],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704458,0.002256109,0.0003844045,0.02490227,0.0005629181,0.0007103459,0.0003842965,0.00002349818,0.0003304154],"genre_scores_gemma":[0.9948594,0.0001982775,0.0001050312,0.0007123097,0.00379682,0.00003781942,0.000125709,0.000002733059,0.0001619227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7823444,"threshold_uncertainty_score":0.9995642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0526612199441704,"score_gpt":0.3150997554401381,"score_spread":0.2624385354959677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}