{"id":"W4309329466","doi":"10.1007/978-1-0716-2772-3_12","title":"Knocking Down DUX4 in Immortalized Facioscapulohumeral Muscular Dystrophy Patient-Derived Muscle Cells","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Facioscapulohumeral muscular dystrophy; Muscular dystrophy; Skeletal muscle; Gene knockdown; Biology; Transcription factor; Cell biology; Gene; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912792,0.0003839224,0.0004171529,0.0003880454,0.0003308185,0.0005008825,0.0003210782,0.0003913721,0.002895131],"category_scores_gemma":[0.0001856889,0.0002139596,0.0004115582,0.0002498337,0.0002955691,0.0001883197,0.0004011882,0.0005742052,0.0007817086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606383,"about_ca_system_score_gemma":0.0002910913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009548823,"about_ca_topic_score_gemma":0.001773156,"domain_scores_codex":[0.9997249,0.00004186977,0.00005277301,0.00006387629,0.00006785481,0.0000487055],"domain_scores_gemma":[0.9998847,0.00003872925,0.00001633277,0.00002276158,0.00001154262,0.00002583861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004577846,0.00002153044,0.0003404399,0.00004314579,0.00001740444,0.0001883551,0.00003930343,0.00008344821,0.9975013,0.0002605486,0.0001330257,0.001325719],"study_design_scores_gemma":[0.00003123208,0.0001224558,0.0049711,0.00001719157,0.00006554982,0.001242733,0.00009119188,0.00158705,0.9767576,0.00008485601,0.0150209,0.00000821101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797335,0.001703426,0.01061751,0.0002453073,0.0002360159,0.00009987901,0.003324259,0.0003836795,0.003656371],"genre_scores_gemma":[0.9743441,0.001101059,0.008463467,0.0001294249,0.00002296588,0.0001204557,0.003277844,0.0001056342,0.01243505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002895131,"threshold_uncertainty_score":0.009685159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00974423670822652,"score_gpt":0.3216768030108259,"score_spread":0.3119325663025994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}