{"id":"W4309348334","doi":"10.1016/j.breast.2022.11.005","title":"Effect of palbociclib plus endocrine therapy on time to chemotherapy across subgroups of patients with hormone receptor‒positive/human epidermal growth factor receptor 2‒negative advanced breast cancer: Post hoc analyses from PALOMA-2 and PALOMA-3","year":2022,"lang":"en","type":"article","venue":"The Breast","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Pfizer","keywords":"Medicine; Palbociclib; Oncology; Human Epidermal Growth Factor Receptor 2; Hormone receptor; Internal medicine; Cancer; Chemotherapy; Breast cancer; Endocrine system; Hormone; Receptor; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004183483,0.001275955,0.003204685,0.0004409823,0.000355223,0.0009198206,0.0008100793,0.000923723,0.003474963],"category_scores_gemma":[0.003352875,0.0004621188,0.005093517,0.0004236497,0.0006750553,0.0009467851,0.0005109257,0.002690269,0.0002921261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001081149,"about_ca_system_score_gemma":0.001833806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110054,"about_ca_topic_score_gemma":0.003230537,"domain_scores_codex":[0.9982148,0.00103889,0.0001240321,0.0002579766,0.00009251887,0.0002718599],"domain_scores_gemma":[0.9962316,0.001741183,0.0006818454,0.0003969263,0.0001800123,0.0007684574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9809479,0.003021579,0.00438992,0.0001119342,0.00245288,0.00002340415,0.00003605216,0.0005045969,0.001815721,0.00002806466,0.0002974437,0.006370599],"study_design_scores_gemma":[0.3920308,0.5141401,0.07344472,0.00004616965,0.01078639,0.0001008937,0.0001333883,0.003438424,0.003990082,0.000344,0.001475193,0.00006978693],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974586,0.0008981793,0.0001609334,0.0001144881,0.00008225026,0.0003513807,0.0004832098,0.00001599601,0.0004349305],"genre_scores_gemma":[0.9968304,0.0003520843,0.000307834,0.000209457,0.00009646382,0.0006528585,0.0008062433,0.00001058387,0.0007340463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004183483,"threshold_uncertainty_score":0.02212465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008396602502152975,"score_gpt":0.2926130271226839,"score_spread":0.2842164246205309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}