{"id":"W4309361185","doi":"10.15252/embj.2022112920","title":"LUBAC and NF‐κB trigger a nuclear response from mitochondria","year":2022,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Mitochondrion; Innate immune system; Cell biology; NF-κB; Nucleus; Signal transduction; Immune system; NFKB1; Nuclear transport; Inner membrane; Cell nucleus; Biochemistry; Gene; Immunology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007286383,0.00009274259,0.00009225718,0.00002591829,0.0005824674,0.00006205396,0.0002666387,0.00003682367,0.00128296],"category_scores_gemma":[0.00009481292,0.00006816319,0.0000763056,0.00004872664,0.00005748176,0.000002794066,0.0002467211,0.0003328875,0.0000276964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001514962,"about_ca_system_score_gemma":0.00006729372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009337525,"about_ca_topic_score_gemma":0.000001635264,"domain_scores_codex":[0.9988401,0.0005338992,0.0001411882,0.0001549882,0.0001568306,0.000173006],"domain_scores_gemma":[0.9995303,0.00004314547,0.00008578991,0.0002310565,0.00002370015,0.00008603241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002247474,0.00003347939,0.00007907925,0.000001175162,0.00006570474,0.00003353551,0.0006576731,0.00001358517,0.9588194,0.00005829587,0.03545525,0.002535376],"study_design_scores_gemma":[0.001197978,0.0004840913,0.001029336,0.000007580426,0.00003346953,0.001041644,0.0008874252,0.00006178987,0.07220528,0.001151905,0.9217094,0.0001901137],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946867,0.001584768,0.00003295257,0.002189546,0.0002981682,0.00009621103,0.00004518983,0.000006594447,0.001059839],"genre_scores_gemma":[0.9945441,0.0001846767,0.0003105238,0.001309608,0.0006421335,0.00001209429,0.00001080808,0.00002568283,0.002960374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8866141,"threshold_uncertainty_score":0.99963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028546644247493,"score_gpt":0.2250307627044116,"score_spread":0.2147452962619366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}