{"id":"W4309361185","doi":"10.15252/embj.2022112920","title":"LUBAC and NF‐κB trigger a nuclear response from mitochondria","year":2022,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Mitochondrion; Innate immune system; Cell biology; NF-κB; Nucleus; Signal transduction; Immune system; NFKB1; Nuclear transport; Inner membrane; Cell nucleus; Biochemistry; Gene; Immunology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005674844,0.0009692286,0.0006077306,0.0007022708,0.0008569827,0.001060235,0.0003378728,0.001165078,0.005074658],"category_scores_gemma":[0.0004369485,0.0004263822,0.0008142503,0.0003796534,0.0006985822,0.001144354,0.0009473528,0.001773546,0.001601247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001214184,"about_ca_system_score_gemma":0.0005119553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005075686,"about_ca_topic_score_gemma":0.0009324072,"domain_scores_codex":[0.9994336,0.00008007813,0.00003784936,0.00008834902,0.0001334221,0.0002266712],"domain_scores_gemma":[0.9996202,0.00005436955,0.00006483508,0.00005425735,0.00006004189,0.0001462257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001512984,0.00005653071,0.0003099062,0.0001414845,0.00002238313,0.0003072031,0.00004836153,0.00006686805,0.9951006,0.0008923009,0.0002067581,0.001334721],"study_design_scores_gemma":[0.0001699015,0.0003409612,0.00566888,0.00002906516,0.00002588792,0.0007489087,0.0002340923,0.0008491903,0.9853901,0.0008635364,0.005658721,0.00002091101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664709,0.0155653,0.007741136,0.002354053,0.0006801336,0.0001033964,0.001042159,0.0004125518,0.005630287],"genre_scores_gemma":[0.9882261,0.001367919,0.002438037,0.0003481456,0.0001268821,0.00007337739,0.0007916136,0.00003788978,0.006590005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005074658,"threshold_uncertainty_score":0.01697642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028546644247493,"score_gpt":0.2250307627044116,"score_spread":0.2147452962619366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}