{"id":"W4309409784","doi":"10.1002/1878-0261.13344","title":"Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Helse Sør-Øst RHF; Universitetet i Oslo; Kreftforeningen","keywords":"Pancreatic cancer; Biology; Cancer research; Cancer; Chemotherapy; Nat; Adenocarcinoma; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004102117,0.0002511725,0.00101792,0.0002404342,0.0001583322,0.0000120713,0.0001460204,0.0001324913,0.0008630172],"category_scores_gemma":[0.00005162343,0.0001930018,0.00003751842,0.0004835258,0.0002374291,0.00006616683,0.0000911993,0.0004778193,0.000002508678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00047664,"about_ca_system_score_gemma":0.001020928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320263,"about_ca_topic_score_gemma":0.0002821609,"domain_scores_codex":[0.9974374,0.0006625047,0.0003087634,0.0005346272,0.0005256666,0.0005311096],"domain_scores_gemma":[0.998975,0.00009730169,0.0001739693,0.0003388521,0.0001671685,0.0002477075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005179782,0.001464674,0.9875541,0.00003220155,0.0005862167,0.0007954577,0.001202767,0.000004949082,0.001312674,0.0000331177,0.00009469994,0.001739349],"study_design_scores_gemma":[0.02042825,0.009187083,0.9675983,0.00004894769,0.000481802,0.000120862,0.000405404,0.000737649,0.0004233812,0.00002608194,0.0003148447,0.0002273799],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958758,0.001051565,0.00002116488,0.0008339111,0.00003761617,0.00163536,0.00007395813,0.00003524333,0.0004353914],"genre_scores_gemma":[0.9958261,0.00004456477,0.0006280919,0.002035169,0.00003021387,0.0009252184,0.0002142356,0.00005805363,0.000238339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0199558,"threshold_uncertainty_score":0.9449434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395685912657892,"score_gpt":0.2978787956107444,"score_spread":0.2839219364841655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}