{"id":"W4309409784","doi":"10.1002/1878-0261.13344","title":"Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Helse Sør-Øst RHF; Universitetet i Oslo; Kreftforeningen","keywords":"Pancreatic cancer; Biology; Cancer research; Cancer; Chemotherapy; Nat; Adenocarcinoma; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380823,0.0001893074,0.0003276118,0.0004759931,0.0002729417,0.0003852828,0.0001048924,0.0002932998,0.0006794239],"category_scores_gemma":[0.0006370321,0.000194255,0.000205782,0.0007055539,0.0002091073,0.0002552762,0.0001989956,0.000304058,0.0001396105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241112,"about_ca_system_score_gemma":0.0001503597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005787459,"about_ca_topic_score_gemma":0.0009004707,"domain_scores_codex":[0.9998592,0.00003098742,0.00002799662,0.00003256566,0.00003166542,0.0000174728],"domain_scores_gemma":[0.9996192,0.00006021748,0.0001976722,0.00002302064,0.00002691136,0.00007288442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001178915,0.00006319357,0.9837154,0.00002525912,0.00005919266,0.0006453787,0.00005431772,0.00009481929,0.01021073,0.00001805571,0.0001112205,0.003823645],"study_design_scores_gemma":[0.000007873808,0.0001247982,0.9978904,0.000003018562,0.0000272325,0.001107696,0.00005962898,0.0001591481,0.0004185616,0.00002009989,0.0001784097,0.000003114658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992575,0.0003345014,0.00005368369,0.00003324179,0.000004445709,0.000003000527,0.0000803859,0.000003928754,0.0002294568],"genre_scores_gemma":[0.9995099,0.0001461953,0.00007021854,0.00001855188,0.000006786794,0.000005027583,0.0001518954,0.000001314802,0.00009006364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006794239,"threshold_uncertainty_score":0.002272904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395685912657892,"score_gpt":0.2978787956107444,"score_spread":0.2839219364841655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}